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Literature summary extracted from

  • Liu, W.; Tanasa, B.; Tyurina, O.; Zhou, T.; Gassmann, R.; Liu, W.; Ohgi, K.; Benner, C.; Garcia-Bassets, I.; Aggarwal, A.; Desai, A.; Dorrestein, P.; Glass, C.; Rosenfeld, M.
    PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression (2010), Nature, 466, 508-512 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.65 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Homo sapiens Q9UPP1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.65 HEK-293T cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
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 Homo sapiens a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 additional information enzyme acts additionally as mono-methyl histone H4 lysine 20 demethylase Homo sapiens ?
-
 ?

General Information

EC Number General Information Comment Organism
1.14.11.65 physiological function PHF8 is recruited to promoters by its PHD domain based on interaction with H3K4me2/3 and controls G1-S transition in conjunction with E2F1, HCF-1 and SET1A, at least in part, by removing the repressive H4K20me1 mark from a subset of E2F1-regulated gene promoters. Phosphorylation-dependent PHF8 dismissal from chromatin in prophase is required for the accumulation of H4K20me1 during early mitosis Homo sapiens