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Literature summary extracted from
- Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 (2019), Nat. Prod. Res., 33, 1765-1768 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.35 | gene MMP9, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.24 | isovitexin | interacts with enzyme residues Glu121, Leu83, Ala84, Pro140, Ile141, His120, Ala136, Leu116, Ala139, and Leu137, binding structure analysis, and modelling, overview | Homo sapiens |  |
| 3.4.24.24 | additional information | Ficus deltoidea leaf extract inhibits matrix metalloproteinase-2, 8 and 9, molecular docking, molecular dynamics, molecular dynamic simulation analysis, overview. Computational docking analysis reveals that vitexin and isovitexin binds to the active site of the three tested MMPs | Homo sapiens | |
| 3.4.24.24 | N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid | NNGH | Homo sapiens | |
| 3.4.24.24 | vitexin | interacts with enzyme residues Leu83, Ala84, His130, Pro140, Ala139, Met138, Ala, 136, Leu137, Thr143, Tyr142, Val117, His120, and Ile141, binding structure analysis, and modelling, overview | Homo sapiens | |
| 3.4.24.34 | isovitexin | interacts with enzyme residues Val112, Ser218, Leu119, Glu118, Asn226, Ser225, Thr224, Asn184, Phe192, and Asp115, binding structure analysis, and modelling, overview | Homo sapiens | |
| 3.4.24.34 | additional information | Ficus deltoidea leaf extract inhibits matrix metalloproteinase-2, 8 and 9, molecular docking, molecular dynamics, molecular dynamic simulation analysis , overview. Computational docking analysis reveals that vitexin and isovitexin binds to the active site of the three tested MMPs | Homo sapiens | |
| 3.4.24.34 | N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid | NNGH | Homo sapiens | |
| 3.4.24.34 | vitexin | interacts with enzyme residues Leu193, Tyr219, Ala161, Asn218, His207, Glu198, Gly158, Pro217, His201, and Val194, binding structure analysis, and modelling, overview | Homo sapiens | |
| 3.4.24.35 | isovitexin | interacts with enzyme residues Glu241, Ala242, Pro255, Pro254, Thr251, Leu222, Tyr248, Arg241, Met247, His226, and Glu227, binding structure analysis, and modeling, overview | Homo sapiens | |
| 3.4.24.35 | additional information | Ficus deltoidea leaf extract inhibits matrix metalloproteinase-2, 8 and 9, molecular docking, molecular dynamics, molecular dynamic simulation analysis, overview. Computational docking analysis reveals that vitexin and isovitexin binds to the active site of the three tested MMPs | Homo sapiens | |
| 3.4.24.35 | N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid | NNGH | Homo sapiens | |
| 3.4.24.35 | vitexin | interacts with enzyme residues Gly186, Pro246, His236, Met247, Tyr248, Val223, and Leu188, binding structure analysis, and modeling, overview | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.24 | Zn2+ | zinc-dependent metalloproteinase | Homo sapiens | |
| 3.4.24.34 | Zn2+ | zinc-dependent metalloproteinase | Homo sapiens | |
| 3.4.24.35 | Zn2+ | zinc-dependent metalloproteinase | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.24 | Homo sapiens | P08253 | - |
- |
| 3.4.24.34 | Homo sapiens | P22894 | - |
- |
| 3.4.24.35 | Homo sapiens | P14780 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.24 | commercial preparation | - |
Homo sapiens | - |
| 3.4.24.24 | EAhy 926 cell | - |
Homo sapiens | - |
| 3.4.24.34 | commercial preparation | - |
Homo sapiens | - |
| 3.4.24.34 | EAhy 926 cell | - |
Homo sapiens | - |
| 3.4.24.35 | commercial preparation | - |
Homo sapiens | - |
| 3.4.24.35 | EAhy 926 cell | - |
Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.24 | matrix metalloproteinase-2 | - |
Homo sapiens |
| 3.4.24.24 | MMP-2 | - |
Homo sapiens |
| 3.4.24.34 | Matrix metalloproteinase-8 | - |
Homo sapiens |
| 3.4.24.34 | MMP-8 | - |
Homo sapiens |
| 3.4.24.35 | matrix metalloproteinase-9 | - |
Homo sapiens |
| 3.4.24.35 | MMP-9 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.24 | 37 | - |
assay at | Homo sapiens |
| 3.4.24.34 | 37 | - |
assay at | Homo sapiens |
| 3.4.24.35 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.24 | 7.4 | - |
assay at | Homo sapiens |
| 3.4.24.34 | 7.4 | - |
assay at | Homo sapiens |
| 3.4.24.35 | 7.4 | - |
assay at | Homo sapiens |
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