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Literature summary extracted from

  • Bhatt, A.; Molle, V.; Besra, G.; Jacobs Jr., W.; Kremer, L.
    The Mycobacterium tuberculosis FAS-II condensing enzymes Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development (2007), Mol. Microbiol., 64, 1442-1454 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.294 n-octanesulfonylacetamide
-
 Mycobacterium tuberculosis
2.3.1.294 thiolactomycin
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.294 Mycobacterium tuberculosis
-
-
-
2.3.1.294 Mycobacterium tuberculosis H37Rv
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.294 phosphoprotein transphosphorylation increases the enzyme activity Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.294 beta-ketoacyl AcpM synthase
-
 Mycobacterium tuberculosis
2.3.1.294 KasB
-
 Mycobacterium tuberculosis
2.3.1.294 Rv2246
-
 Mycobacterium tuberculosis

Expression

EC Number Organism Comment Expression
2.3.1.294 Mycobacterium tuberculosis the enzyme is up-regulated under aerobic conditions up

General Information

EC Number General Information Comment Organism
2.3.1.294 physiological function the enzyme is involved in cording and acid-fast staining and is required for survival and virulence in infected mice Mycobacterium tuberculosis