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Literature summary extracted from

  • Stamogiannos, A.; Koumantou, D.; Papakyriakou, A.; Stratikos, E.
    Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1 (2015), Mol. Immunol., 67, 426-435 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.22
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.11.22 molecular dynamics simulation of mutants K228R, Q730E, R528R/Q730E. The K528R polymorphism has strong effects on the conformational distribution of ERAP1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.11.22 K528R single nucelotide polymorphism, about 50% of wild-type activtiy with fluorogenic substrate L-leucine-7-amido-4-methylcoumarin. Mutation of position 528 does not appear to affect length selection, but rather affects enzyme activity in a uniform manner Homo sapiens
3.4.11.22 K528R/Q730E combination of single nucleotide polymorphisms, activity similar to wild-type. The effects of mutations K528R and Q730E are independent and additive Homo sapiens
3.4.11.22 Q730E single nucelotide polymorphism, about 2000% of wild-type activtiy with fluorogenic substrate L-leucine-7-amido-4-methylcoumarin. Mutation at position 730 leads to an increased preference for smaller peptides Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.22 Homo sapiens Q9NZ08
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.22 L-leucine-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-leucine + 7-amino-4-methylcoumarin
-
 ?
3.4.11.22 LGGGGGGGGGGL + H2O
-
 Homo sapiens L-leucine + GGGGGGGGGGL
-
 ?
3.4.11.22 LGGGGGGGGGL + H2O
-
 Homo sapiens L-leucine + GGGGGGGGGL
-
 ?
3.4.11.22 LGGGL + H2O
-
 Homo sapiens L-leucine + GGGL
-
 ?
3.4.11.22 additional information trimming of the N-terminal leucine residue by ERAP1 is faster for larger peptides of more than 10 residues long Homo sapiens ?
-
 ?