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Literature summary extracted from

  • Aynapudi, J.; El-Rami, F.; Ge, X.; Stone, V.; Zhu, B.; Kitten, T.; Xu, P.
    Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation (2017), Microbiology, 163, 1306-1318 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.89 additional information generation of the biofilm mutant, DELTASSA_0351, that is deficient in type I signal peptidase (SPase). Although the growth curve of the DSSA_0351 mutant shows no significant difference from that of the wild-type strain SK36, biofilm assays using both microtitre plate assay and confocal laser scanning microscopy (CLSM) confirmed a sharp reduction in biofilm formation in the mutant compared to the wild-type strain and the paralogous mutant DSSA_0849. Evaluation of the functional impact of SPase on biofilm formation, transcriptome analysis compared to wild-type, overview. The growth rates of the wild-type, DSSA_0849 and DSSA_0351 strains are not significantly different. Proteomic analysis of mutant strain DELTASSA_0351, list of transcripts that are differentially regulated in DELTASSA_0351 Streptococcus sanguinis

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.89 Streptococcus sanguinis A3CKV0
-
-
3.4.21.89 Streptococcus sanguinis SK36 A3CKV0
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.89 SPase
-
 Streptococcus sanguinis
3.4.21.89 type I signal peptidase
-
 Streptococcus sanguinis

General Information

EC Number General Information Comment Organism
3.4.21.89 malfunction the biofilm mutant, DELTASSA_0351, is deficient in type I signal peptidase (SPase), phenotype, overview. Proteomic analysis of mutant strain DELTASSA_0351, list of transcripts that are differentially regulated in DELTASSA_0351 Streptococcus sanguinis
3.4.21.89 physiological function involvement of signal peptidase I in Streptococcus sanguinis biofilm formation. Streptococcus sanguinis, a Gram-positive bacterium, is one of the most abundant species of the oral microbiota and it contributes to biofilm development in the oral cavity Streptococcus sanguinis