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Literature summary extracted from

  • Yang, D.; Qin, W.; Shi, X.; Zhu, B.; Xie, M.; Zhao, H.; Teng, B.; Wu, Y.; Zhao, R.; Yin, F.; Ren, P.; Liu, L.; Li, Z.
    Stabilized beta-hairpin peptide inhibits insulin degrading enzyme (2018), J. Med. Chem., 61, 8174-8185 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.56 medicine peptide inhibitors cand function as potentially meaningful candidates for the development of type-2 diabetes therapeutics Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 Ac-EWRFCGdPPECLYLVCG-NH2(Cys5-Cys10 disulfide)
-
 Mus musculus
3.4.24.56 Ac-EWRFCGGGdPPECLYLVCG-NH2(Cys5-Cys12-disulfide)
-
 Mus musculus
3.4.24.56 EALYLVCG-NH2
-
 Mus musculus
3.4.24.56 EALYLVCGdPPFRWE-NH2
-
 Mus musculus
3.4.24.56 EWRF-cyclo(DGdPPEDap)LYLVCG-NH2
-
 Mus musculus
3.4.24.56 EWRF-cyclo(DGGGdPPEDap)LYLVCG-NH2
-
 Mus musculus
3.4.24.56 EWRFdPPEALY-NH2
-
 Mus musculus
3.4.24.56 EWRFdPPEALYLV-NH2
-
 Mus musculus
3.4.24.56 EWRFGGEALYLVCG-NH2
-
 Mus musculus
3.4.24.56 RFdPPEALY-NH2
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Mus musculus the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Mus musculus Q9JHR7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 insulin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.56 insulin + H2O the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin Mus musculus ?
-
 ?
3.4.24.56 [(7-methoxycoumarin-4-yl)acetyl]-RPPGFSAFK(Dnp)-OH + H2O
-
 Mus musculus [(7-methoxycoumarin-4-yl)acetyl]-RPPGF + SAFK(Dnp)-OH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 insulin degrading enzyme
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.56 0.000022
-
 pH 7.5, 23°C Mus musculus EWRF-cyclo(DGdPPEDap)LYLVCG-NH2
3.4.24.56 0.000044
-
 pH 7.5, 23°C Mus musculus EWRF-cyclo(DGGGdPPEDap)LYLVCG-NH2
3.4.24.56 0.00006
-
 pH 7.5, 23°C Mus musculus Ac-EWRFCGdPPECLYLVCG-NH2(Cys5-Cys10 disulfide)
3.4.24.56 0.000077
-
 pH 7.5, 23°C Mus musculus Ac-EWRFCGGGdPPECLYLVCG-NH2(Cys5-Cys12-disulfide)
3.4.24.56 0.000086
-
 pH 7.5, 23°C Mus musculus EWRFdPPEALYLV-NH2
3.4.24.56 0.00017
-
 pH 7.5, 23°C Mus musculus EALYLVCGdPPFRWE-NH2
3.4.24.56 0.00023
-
 pH 7.5, 23°C Mus musculus EALYLVCG-NH2
3.4.24.56 0.0003
-
 pH 7.5, 23°C Mus musculus EWRFGGEALYLVCG-NH2
3.4.24.56 0.000601
-
 pH 7.5, 23°C Mus musculus EWRFdPPEALY-NH2

General Information

EC Number General Information Comment Organism
3.4.24.56 physiological function the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin Mus musculus