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Literature summary extracted from

  • Tan, X.F.; Kim, D.W.; Song, Y.H.; Kim, J.Y.; Yuk, H.J.; Wang, Y.; Curtis-Long, M.J.; Park, K.H.
    Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics (2016), J. Enzyme Inhib. Med. Chem., 31, 16-22 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 (2R, 3R)-6-methyl-3'-geranyl-2,3-trans-5,7,4'-trihydroxyflavonol
-
 Homo sapiens
3.4.21.37 (E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one competitive inhibitor Homo sapiens
3.4.21.37 3'-geranyl-5,7,2',4'-tetrahydroxyisoflavanone
-
 Homo sapiens
3.4.21.37 additional information not inhibited by dalbergioidin, 3(S)-2',4'-dihydroxy-5,5'-dimethoxy-(6'',6''-dimethylpyano)-(2'',3'':7,6)-isoflavan, myrsininone A, isosophoranone, myrsininone B, and 3'-geranyl-5,7,2',5'-tetrahydroxyisoflavone Homo sapiens
3.4.21.37 oleanolic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O Homo sapiens
-
 methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroanilide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroanilide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 HNE
-
 Homo sapiens
3.4.21.37 neutrophil elastase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.37 0.01634
-
 (E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one at pH 8.0, temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.37 0.0085
-
 at pH 8.0, temperature not specified in the publication Homo sapiens (E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one
3.4.21.37 0.0179
-
 at pH 8.0, temperature not specified in the publication Homo sapiens (2R, 3R)-6-methyl-3'-geranyl-2,3-trans-5,7,4'-trihydroxyflavonol
3.4.21.37 0.02168
-
 at pH 8.0, temperature not specified in the publication Homo sapiens oleanolic acid
3.4.21.37 0.0308
-
 at pH 8.0, temperature not specified in the publication Homo sapiens 3'-geranyl-5,7,2',4'-tetrahydroxyisoflavanone