Literature summary extracted from

Li, Y.; Quan, X.; Li, X.; Pan, Y.; Zhang, T.; Liang, Z.; Wang, Y.
Kdm6A protects against hypoxia-induced cardiomyocyte apoptosis via H3K27me3 demethylation of Ncx gene (2019), J. Cardiovasc. Transl. Res., 12, 488-495 .

Application

EC Number	Application	Comment	Organism
1.14.11.68	medicine	demethylase Kdm6a expression is significantly upregulated in a rat acute myocardial infarction model and in hypoxia induction	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.11.68	Rattus norvegicus	A0A0G2K6D0	isoform Kdm6a	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.11.68	cardiomyocyte	cardiomyocyzes cultured in vitro	Rattus norvegicus	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.11.68	KDM6A	-	Rattus norvegicus

General Information

EC Number	General Information	Comment	Organism
1.14.11.68	physiological function	the apoptosis rate of cardiomyocytes is significantly exacerbated when Kdm6a is knocked down. The expression of the Na+/Ca2+ exchanger Ncx is significantly upregulated in cardiomyocytes under hypoxia. Knockdown of Kdm6a downregulates the Ncx expression via enhancing H3K27me3 modification on Ncx gene promoter, and attenuates the intracellular calcium-influx ability in cardiomyocytes as a consequence	Rattus norvegicus

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Release 2023.1 (January 2023)