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Literature summary extracted from

  • Patil, A.G.; Sang, P.B.; Govindan, A.; Varshney, U.
    Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance (2013), J. Biol. Chem., 288, 11252-11262 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.69 expression in Escherichia coli Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.69 0.05
-
 8-oxo-dGTP pH 8.0, 37°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.69 8-oxo-dGTP + H2O Mycobacterium tuberculosis
-
 8-oxo-dGDP + phosphate
-
 ?
3.6.1.69 8-oxo-dGTP + H2O Mycobacterium tuberculosis H37Rv
-
 8-oxo-dGDP + phosphate
-
 ?
3.6.1.69 8-oxo-GTP + H2O Mycobacterium tuberculosis
-
 8-oxo-GDP + phosphate
-
 ?
3.6.1.69 8-oxo-GTP + H2O Mycobacterium tuberculosis H37Rv
-
 8-oxo-GDP + phosphate
-
 ?
3.6.1.69 additional information Mycobacterium tuberculosis no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP ?
-
 ?
3.6.1.69 additional information Mycobacterium tuberculosis H37Rv no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.69 Mycobacterium tuberculosis P9WIY3
-
-
3.6.1.69 Mycobacterium tuberculosis H37Rv P9WIY3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.69 recombinant protein Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.69 8-oxo-dGTP + H2O
-
 Mycobacterium tuberculosis 8-oxo-dGDP + phosphate
-
 ?
3.6.1.69 8-oxo-dGTP + H2O
-
 Mycobacterium tuberculosis H37Rv 8-oxo-dGDP + phosphate
-
 ?
3.6.1.69 8-oxo-GTP + H2O
-
 Mycobacterium tuberculosis 8-oxo-GDP + phosphate
-
 ?
3.6.1.69 8-oxo-GTP + H2O
-
 Mycobacterium tuberculosis H37Rv 8-oxo-GDP + phosphate
-
 ?
3.6.1.69 additional information no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP Mycobacterium tuberculosis ?
-
 ?
3.6.1.69 additional information no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.69 mutT1
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.6.1.69 physiological function MutT1 converts 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP. Rv1700 then converts them to the corresponding nucleoside monophosphates. An Escherichia coli strain expressing both MutT1 and Rv100 is rescued during treatment with 2 mM H2O2 Mycobacterium tuberculosis