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Literature summary extracted from

  • Lahiri, S.; Futerman, A.H.
    LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor (2005), J. Biol. Chem., 280, 33735-33738 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.291 fumonisin B1
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.291 Mus musculus Q9D6K9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.291 additional information the enzyme is higly selective toward palmitoyl-CoA as acyl donor Mus musculus ?
-
 ?
2.3.1.291 palmitoyl-CoA + a sphingoid base
-
 Mus musculus an N-(palmitoyl)-sphingoid base + CoA
-
 ?
2.3.1.291 stearoyl-CoA + a sphingoid base about 10% of the activity with palmitoyl-CoA Mus musculus an N-(stearoyl)-sphingoid base + CoA
-
 ?

General Information

EC Number General Information Comment Organism
2.3.1.291 physiological function overexpression of LASS elevates the synthesis of (dihydro)ceramides selectively enriched in palmitic acid Mus musculus