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Literature summary extracted from

  • Gonzalez, D.; Karaveg, K.; Vandersall-Nairn, A.; Lal, A.; Moremen, K.
    Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis (1999), J. Biol. Chem., 274, 21375-21386 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.113 enzyme-protein A-fusion protein is expressed in COS cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.113 deoxymannojirimycin
-
 Homo sapiens
3.2.1.113 EDTA the enzyme inhibition by EDTA can be reversed by the addition of Ca2+ and to a lesser extent by Fe2+ and Mn2+ Homo sapiens
3.2.1.113 EGTA the enzyme inhibition by EGTA can be reversed by the addition of Ca2+ and to a lesser extent by Fe2+ and Mn2+ Homo sapiens
3.2.1.113 kifunensine
-
 Homo sapiens
3.2.1.113 additional information not inhibited by swainsonine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.113 endoplasmic reticulum
-
 Homo sapiens 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.113 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.113 Man9GlcNAc2-Asn + H2O Homo sapiens
-
 Man8GlcNAc2-Asn (isomer 8A1,2,3B1,3) + D-mannose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.113 Homo sapiens Q9UKM7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.113 IgG-Sepharose bead chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.113 Man9GlcNAc2-Asn + H2O
-
 Homo sapiens Man8GlcNAc2-Asn (isomer 8A1,2,3B1,3) + D-mannose
-
 ?
3.2.1.113 Man9GlcNAc2-pyridylamine + H2O
-
 Homo sapiens Man8GlcNAc2-pyridylamine (isomer 8A1,2,3B1,3) + D-mannose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.113 alpha1,2-mannosidase I
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.113 7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.2.1.113 6 8 the enzyme is active between pH 6.0 and 8.0 Homo sapiens

General Information

EC Number General Information Comment Organism
3.2.1.113 metabolism the enzyme catalyzes the first mannose trimming step in the processing of mammalian Asn-linked oligosaccharides Homo sapiens