EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.15.1 | (-)-epigallocatechin gallate | - |
Rattus norvegicus | |
3.4.15.1 | 5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid | - |
Rattus norvegicus | |
3.4.15.1 | 5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone | the metabolite has a hypotensive effect in vivo | Rattus norvegicus | |
3.4.15.1 | 5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid | - |
Rattus norvegicus | |
3.4.15.1 | 5-(3,5-dihydroxyphenyl)-gamma-valerolactone | the metabolite has a hypotensive effect in vivo | Rattus norvegicus | |
3.4.15.1 | additional information | effects of metabolites produced from (-)-epigallocatechin gallate by rat intestinal bacteria on angiotensin I-converting enzyme activity and blood pressure in spontaneously hypertensive rats. All of the metabolites show ACE inhibitory activities and the order of IC50 is hydroxyphenyl valeric acids > 5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone > 5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl)-gamma-valerolactone. Among the catechins, galloylated catechins exhibit stronger ACE inhibitory activity than nongalloylated catechins. Measurement of systolic blood pressure (SBP) after oral administration | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + L-His-L-Leu | - |
? | |
3.4.15.1 | angiotensin I + H2O | Rattus norvegicus Wistar | - |
angiotensin II + L-His-L-Leu | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.15.1 | Rattus norvegicus | P47820 | spontaneously hypertensive rats, SHR | - |
3.4.15.1 | Rattus norvegicus Wistar | P47820 | spontaneously hypertensive rats, SHR | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + L-His-L-Leu | - |
? | |
3.4.15.1 | angiotensin I + H2O | - |
Rattus norvegicus Wistar | angiotensin II + L-His-L-Leu | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.15.1 | ACE | - |
Rattus norvegicus |
3.4.15.1 | angiotensin I-converting enzyme | - |
Rattus norvegicus |