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Literature summary extracted from

  • Ruixadz-Sanjuan, M.; Martinez-Martos, J.; Carrera-Gonzalez, M.; Mayas, M.; Garcia, M.; Arrazola, M.; Ramirez-Exposito, M.
    Normolipidic dietary fat modifies circulating renin-angiotensin system-regulating aminopeptidase activities in rat with breast cancer (2015), Integr. Cancer Ther., 14, 149-155 .
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.11.3 diagnostics the increase in serum IRAP activity can be an indicator of a misregulation of vasopressin (AVP) function Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.3 Zn2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.3 Vasopressin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Rattus norvegicus P97629
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 adipocyte
-
 Rattus norvegicus
-
3.4.11.3 breast cancer cell N-methyl nitrosourea (NMU)-induced breast cancer Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 leucyl-beta-naphthylamide + H2O
-
 Rattus norvegicus leucine + beta-naphthylamine
-
 ?
3.4.11.3 Vasopressin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.3 insulin-regulated aminopeptidase
-
 Rattus norvegicus
3.4.11.3 IRAP
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.11.3 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.3 7.4
-
 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.11.3 metabolism the type of dietary fat does not influence latency period, incidence of animals with tumors, incidence of mortality, or tumor yield per rat. However, changes are observed in tumor volume and the histopathology. The type of dietary fat also differently modifies the enzymes involved in RAS regulation. Both insulin-regulated aminopeptidase (IRAP) and angiotensin IV forming activities are involved in this animal model of breast pathogenesis. The increase in serum IRAP activity can be an indicator of a misregulation of vasopressin (AVP) function Rattus norvegicus