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Literature summary extracted from

  • Chen, Y.; Liu, Z.; Pan, T.; Chen, E.; Mao, E.; Chen, Y.; Tan, R.; Wang, X.; Tian, R.; Liu, J.; Qu, H.
    JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis (2018), Int. Immunopharmacol., 59, 40-46 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.68 gene KDM6B, quantitative real-time PCR enzyme expression analysis Homo sapiens
3.4.21.76 gene PRTN3, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.68 GSK-J4 both the mRNA and protein levels of mPR3 are significantly reduced compared to controls Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.68 nucleus
-
 Homo sapiens 5634
-
3.4.21.76 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.68 [histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.68 Homo sapiens O15054
-
-
3.4.21.76 Homo sapiens P24158
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.68 neutrophil neutrophil JMJD3 expression is increased in patients with sepsis Homo sapiens
-
1.14.11.68 THP-1 cell
-
 Homo sapiens
-
3.4.21.76 additional information the neutrophil membrane mPR3 is highly induced in patients with sepsis Homo sapiens
-
3.4.21.76 neutrophil
-
 Homo sapiens
-
3.4.21.76 THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.68 [histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.68 histone demethylase
-
 Homo sapiens
1.14.11.68 JMJD3
-
 Homo sapiens
1.14.11.68 KDM6B
-
 Homo sapiens
3.4.21.76 membrane proteinase 3
-
 Homo sapiens
3.4.21.76 mPR3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.11.68 Homo sapiens GSK-J4 reduces both the mRNA and protein levels of mPR3 significantly compared to controls down
1.14.11.68 Homo sapiens lipopolysaccharide (LPS) induces JMJD3 expression in vitro. Neutrophil JMJD3 expression is increased in patients with sepsis compared to controls up
3.4.21.76 Homo sapiens histone demethylase JMJD3 (EC 1.14.11.68) regulates the expression of neutrophil membrane proteinase 3 (mPR3) in lipopolysaccharide-stimulated neutrophils during the early inflammatory response in sepsis up

General Information

EC Number General Information Comment Organism
1.14.11.68 physiological function histone demethylase JMJD3 regulates the expression of neutrophil membrane proteinase 3 (mPR3, EC 3.4.21.76) in lipopolysaccharide-stimulated neutrophils, mostly during the early inflammatory response in sepsis. JMJD3 regulates the expression of mPR3 by changing the level of H3K27me3 in LPS-stimulated neutrophils Homo sapiens
3.4.21.76 metabolism histone demethylase JMJD3 (EC 1.14.11.68) regulates the expression of neutrophil membrane proteinase 3 (mPR3) in lipopolysaccharide-stimulated neutrophils during the early inflammatory response in sepsis. JMJD3 regulates the expression of mPR3 by changing the level of trimethylated histone H3 on Lys27 (H3K27me3) in LPS-stimulated neutrophils Homo sapiens
3.4.21.76 physiological function membrane proteinase 3 (mPR3) expression on neutrophils plays a critical role in pro-inflammatory cytokine production. Plasma cytokine (interleukin-1beta and TNF-alpha) levels are increased in patients with sepsis exhibiting high mPR3 expression Homo sapiens