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Literature summary extracted from

  • Casciello, F.; Windloch, K.; Gannon, F.; Lee, J.S.
    Functional role of G9a histone methyltransferase in cancer (2015), Front. Immunol., 6, 487 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.355 BIX-01294 diazepin-quinazolin-amine derivative, specific competitive inhibitor Mus musculus
2.1.1.355 UNC0638
-
 Mus musculus
2.1.1.355 UNC0642
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
2.1.1.355 additional information Mus musculus the enzyme is automethylated at K239 ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + ACINUS Mus musculus
-
 ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + CDYL1 Mus musculus
-
 ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + p53 Mus musculus the enzyme is responsible for p53 methylation at lysine 373 ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + reptin Mus musculus the enzyme is responsible for reptin methylation at lysine 67 ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + WIZ Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Mus musculus Q9Z148
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
2.1.1.355 additional information the enzyme is automethylated at K239 Mus musculus ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 r
2.1.1.355 S-adenosyl-L-methionine + ACINUS
-
 Mus musculus ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + CDYL1
-
 Mus musculus ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + p53 the enzyme is responsible for p53 methylation at lysine 373 Mus musculus ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + reptin the enzyme is responsible for reptin methylation at lysine 67 Mus musculus ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + WIZ
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 EHMT2
-
 Mus musculus
2.1.1.355 G9a
-
 Mus musculus
2.1.1.355 H3K9 methyltransferase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.355 Mus musculus the enzyme is overexpressed in a number of cancers, including esophageal squamous cell carcinoma, hepato-cellular carcinoma, aggressive lung cancer, brain cancer, multiple myeloma, and aggressive ovarian carcinoma up

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction enzyme depletion results in embryonic lethality with severe differentiation defects in embryonic stem cells. Enzyme depletion inhibits cell proliferation in several cancer cell lines Mus musculus
2.1.1.355 physiological function the enzyme is essential for the repression of developmental genes and is required during development Mus musculus