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Literature summary extracted from

  • Kumar, S.; Gurshaney, S.; Adagunodo, Y.; Gage, E.; Qadri, S.; Sharma, M.; Malik, S.; Manne, U.; Singh, U.P.; Singh, R.; Mishra, M.K.
    Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer (2018), Front. Biosci., 23, 1987-2000 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.77 diagnostics the gama-SM/PSA, a protein member of the kallikrein family, is the most prominent biomarker for prostate cancer, PCa. Hsp70 can also be used as a co-biomarker for PCa with gama-SM Homo sapiens
3.4.21.77 drug development the gama-SM protein can be a drug target in prostate cancer therapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.77 3-nitrophenyl boronic acid inhibits PSA Homo sapiens
3.4.21.77 alpha1-Antichymotrypsin inhibits PSA Homo sapiens
3.4.21.77 Boric acid inhibits PSA Homo sapiens
3.4.21.77 dutasteride inhibits PSA Homo sapiens
3.4.21.77 finasteride inhibits PSA Homo sapiens
3.4.21.77 norleucine inhibits PSA Homo sapiens
3.4.21.77 norvaline inhibits PSA Homo sapiens
3.4.21.77 Z-SSKL(boro)L inhibits PSA Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.77 Homo sapiens P07288
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.77 gama-SM protein
-
 Homo sapiens
3.4.21.77 prostate-specific antigen
-
 Homo sapiens
3.4.21.77 PSA
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.77 metabolism the HSP protein family and the gama-SM protein are related in two critical ways: the fact that silencing HSPs may be directly correlated with reduced gama-SM protein expression and their high potential as biomarkers for PCa. A direct proportional relationship between Hsp70 and the gama-SM protein Homo sapiens