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Literature summary extracted from

  • Chlebek, J.; De Simone, A.; Hostalkova, A.; Opletal, L.; Perez, C.; Perez, D.I.; Havlikova, L.; Cahlikova, L.; Andrisano, V.
    Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimers disease targets (2016), Fitoterapia, 109, 241-247 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.46 (+)-canadaline 41.02% inhibition at 0.005 mM Homo sapiens
3.4.23.46 (+)-corynoline 21.91% inhibition at 0.005 mM Homo sapiens
3.4.23.46 (+/-)-corycavidine 26.87% inhibition at 0.005 mM Homo sapiens
3.4.23.46 (-)-corycavamine 34.4% inhibition at 0.005 mM Homo sapiens
3.4.23.46 (-)-isocorypalmine 26.68% inhibition at 0.005 mM Homo sapiens
3.4.23.46 (-)-scoulerine 24.34% inhibition at 0.005 mM Homo sapiens
3.4.23.46 Allocryptopine 26.18% inhibition at 0.005 mM Homo sapiens
3.4.23.46 additional information not inhibited by 0.005 mM (+)-canadine, (+)-corydaline, (+)-tetrahydropalmatine, (+)-corydine, (+)-bulbocapnine, (+)-corypalmine, (-)-sinoacutine, and (+)-N-methyllaurotetanine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.46 amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.46 Homo sapiens P56817
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.46 amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.46 M-2420 + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.46 rhodamine-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-quencher + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.46 BACE1
-
 Homo sapiens
3.4.23.46 beta-site amyloid precursor protein cleaving enzyme 1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.23.46 0.03359
-
 at pH 4.0 and 25°C Homo sapiens (+)-corynoline
3.4.23.46 0.04116
-
 at pH 4.0 and 25°C Homo sapiens (-)-corycavamine