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Literature summary extracted from

  • Forneris, F.; Binda, C.; Vanoni, M.A.; Mattevi, A.; Battaglioli, E.
    Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process (2005), FEBS Lett., 579, 2203-2207 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.99.66 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.66 a [histone H3]-N6,N6-dimethyl-L-lysine4 + O2 + 2 H2O Homo sapiens
-
 a [histone H3]-L-lysine4 + 2 formaldehyde + 2 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.66 Homo sapiens O60341
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.66 a [histone H3]-N6,N6-dimethyl-L-lysine4 + ferricenium + H2O
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine4 + formaldehyde + ferrocene
-
 ?
1.14.99.66 a [histone H3]-N6,N6-dimethyl-L-lysine4 + O2 + 2 H2O
-
 Homo sapiens a [histone H3]-L-lysine4 + 2 formaldehyde + 2 H2O2
-
 ?
1.14.99.66 a [histone H3]-N6-methyl-L-lysine4 + acceptor + H2O
-
 Homo sapiens a [histone H3]-L-lysine4 + formaldehyde + reduced acceptor
-
 ?
1.14.99.66 additional information no substrates: dimethylated histone H3 K9 residues Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.66 KDM1A
-
 Homo sapiens
1.14.99.66 LSD1
-
 Homo sapiens
1.14.99.66 lysine-specific histone demethylase 1A
-
 Homo sapiens