3.2.1.B23
ginsenoside C-K + H2O
Rhizobium sp.
protopanaxadiol + D-glucose
?
3.2.1.B23
ginsenoside C-O + H2O
Bifidobacterium choerinum
ginsenoside F2 + L-arabinopyranose
?
3.2.1.B23
ginsenoside G17 + H2O
Thermus thermophilus
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Bifidobacterium longum
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Flavobacterium johnsoniae
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Bifidobacterium longum H-1
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G75 + H2O
Thermus thermophilus
ginsenoside C-K + D-glucose
?
3.2.1.B23
ginsenoside Mc + H2O
Caldicellulosiruptor saccharolyticus
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc + H2O
Rhodanobacter ginsenosidimutans
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc1 + H2O
Rhodanobacter ginsenosidimutans
ginsenoside F2 + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Thermus thermophilus
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Trichoderma viride
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Aspergillus sp.
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Bifidobacterium longum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Lissachatina fulica
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Passalora fulva
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudothermotoga thermarum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Flavobacterium johnsoniae
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Aspergillus niger
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudonocardia sp.
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Microbacterium esteraromaticum
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Bifidobacterium longum H-1
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudothermotoga thermarum DSM 5069T
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Bifidobacterium choerinum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Microbacterium esteraromaticum
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.B23
ginsenoside Rb3 + H2O
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose + D-xylose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium breve
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Caldicellulosiruptor saccharolyticus
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Panax ginseng
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Leuconostoc sp.
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Rhodanobacter ginsenosidimutans
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium longum H-1
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rd + H2O
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose
?
3.2.1.B23
ginsenoside Re + H2O
Mucilaginibacter sp. QM49
ginsenoside Rg2 + D-glucose
?
3.2.1.B23
ginsenoside Rg1 + H2O
Mucilaginibacter sp. QM49
ginsenoside Rh1 + D-glucose
?
3.2.1.B23
additional information
Thermus thermophilus
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Trichoderma viride
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Aspergillus sp.
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium longum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Lissachatina fulica
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Passalora fulva
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Pseudothermotoga thermarum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Flavobacterium johnsoniae
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium breve
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Trichoderma viride
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Caldicellulosiruptor saccharolyticus
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium longum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium choerinum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium longum H-1
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium longum H-1
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Pseudothermotoga thermarum DSM 5069T
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.191
ginsenoside Rb1 + H2O
Sphingomonas sp.
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Sphingopyxis alaskensis
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Esteya vermicola
via ginsenoside G17
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Esteya vermicola CNU120806
via ginsenoside G17
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
Sphingomonas sp.
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
Sphingopyxis alaskensis
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
Sphingomonas sp.
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
Sphingopyxis alaskensis
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Esteya vermicola
via ginsenosside F2
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Sphingomonas sp.
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Sphingopyxis alaskensis
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Esteya vermicola CNU120806
via ginsenosside F2
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium sp.
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium proliferatum
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Panax ginseng
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Sphingopyxis alaskensis
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium proliferatum ECU2042
ginsenoside Rh2 + D-glucose
?
3.2.1.191
additional information
Aspergillus niger
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium sp.
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Sphingomonas sp.
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium proliferatum
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Panax ginseng
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Terrabacter ginsenosidimutans
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Sphingopyxis alaskensis
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Esteya vermicola
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Esteya vermicola CNU120806
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium proliferatum ECU2042
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.193
ginsenoside F2 + H2O
Sphingomonas leidyi
ginsenoside C-K + D-glucose
?
3.2.1.193
ginsenoside F2 + H2O
Aspergillus oryzae
ginsenoside C-K + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc citreum
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sulfolobus acidocaldarius
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc mesenteroides
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Lactiplantibacillus pentosus
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Microbacterium esteraromaticum
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Fusobacterium sp.
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Companilactobacillus paralimentarius
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sphingomonas leidyi
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus niger
via ginsenosides Rd and F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus oryzae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Intrasporangium sp.
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Globisporangium irregulare
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Nocardioides panaciterrulae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sphingomonas leidyi
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Byssochlamys spectabilis
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Citrus limon
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Lactiplantibacillus pentosus 6105
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Intrasporangium sp. GS603
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc mesenteroides DC102
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc citreum LH1
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus niger g.848
via ginsenosides Rd and F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Sulfolobus acidocaldarius
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Microbacterium esteraromaticum
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus niger
via ginsenosides Rd and F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus niger g.848
via ginsenosides Rd and F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb3 + H2O
Aspergillus niger
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rb3 + H2O
Aspergillus niger g.848
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Nocardioides panaciterrulae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus niger
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus niger g.848
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rd + H2O
Byssochlamys spectabilis
ginsenoside Rg3 + D-glucose
?
3.2.1.193
ginsenoside Rd + H2O
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + D-glucose
?
3.2.1.193
additional information
Aspergillus niger
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Byssochlamys spectabilis
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Sulfolobus acidocaldarius
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc mesenteroides
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Lactiplantibacillus pentosus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Saccharolobus solfataricus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus oryzae
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Microbacterium esteraromaticum
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Citrus limon
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc citreum
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Fusobacterium sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Pseudarthrobacter chlorophenolicus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Intrasporangium sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Globisporangium irregulare
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Nocardioides panaciterrulae
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Companilactobacillus paralimentarius
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Sphingomonas leidyi
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Byssochlamys spectabilis 229-7
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Lactiplantibacillus pentosus 6105
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Intrasporangium sp. GS603
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc mesenteroides DC102
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc citreum LH1
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus niger g.848
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.194
ginsenoside R1 + H2O
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Pyrococcus furiosus
ginsenoside Rg1 + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Penicillium decumbens
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rf + H2O
Aspergillus niger
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Pyrococcus furiosus
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Aspergillus sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Penicillium decumbens
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Penicillium decumbens
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Fusarium subglutinans
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Penicillium sclerotiorum
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Sanguibacter keddieii
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg2 + 2 H2O
Penicillium decumbens
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Pyrococcus furiosus
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Absidia sp. (in: Fungi)
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Aspergillus sp.
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rh1 + H2O
Penicillium decumbens
protopanaxatriol + D-glucose
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
?
?
3.2.1.194
additional information
Aspergillus niger
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Aspergillus niger
?
?
3.2.1.194
additional information
Absidia sp. (in: Fungi)
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
?
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion was performed using b-glycosidase from Pyrococcus furiosus
?
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Thermoanaerobacterium thermosaccharolyticum
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Penicillium decumbens
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Fusarium subglutinans
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Penicillium sclerotiorum
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Sanguibacter keddieii
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Aspergillus sp.
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
?
?
3.2.1.194
notoginsenoside R1 + H2O
Pyrococcus furiosus
ginsenoside Rg1 + D-xylose
?
3.2.1.194
notoginsenoside R1 + H2O
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rg1 + D-xylose
?
3.2.1.195
ginsenoside Re + H2O
Penicillium sp.
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Re + H2O
Actinosynnema mirum
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Rg1 + H2O
Penicillium sp.
via ginsenoside Rh1
protopanaxatriol + 2 D-glucose
?
3.2.1.195
ginsenoside Rg1 + H2O
Actinosynnema mirum
via ginsenoside Rh1
protopanaxatriol + 2 D-glucose
?
3.2.1.195
additional information
Penicillium sp.
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
?
?
3.2.1.195
additional information
Actinosynnema mirum
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
?
?
3.2.1.B23
ginsenoside C-K + H2O
753334
Rhizobium sp.
protopanaxadiol + D-glucose
?
3.2.1.B23
ginsenoside C-O + H2O
753334
Bifidobacterium choerinum
ginsenoside F2 + L-arabinopyranose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Thermus thermophilus
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Bifidobacterium longum
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Flavobacterium johnsoniae
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Bifidobacterium longum H-1
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G75 + H2O
753334
Thermus thermophilus
ginsenoside C-K + D-glucose
?
3.2.1.B23
ginsenoside Mc + H2O
753334
Caldicellulosiruptor saccharolyticus
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc1 + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside F2 + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Thermus thermophilus
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Trichoderma viride
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Aspergillus sp.
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Bifidobacterium longum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Lissachatina fulica
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Passalora fulva
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudothermotoga thermarum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Flavobacterium johnsoniae
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Bifidobacterium longum H-1
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudothermotoga thermarum DSM 5069T
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Aspergillus niger
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Microbacterium esteraromaticum
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Bifidobacterium choerinum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Microbacterium esteraromaticum
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.B23
ginsenoside Rb3 + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose + D-xylose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium breve
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Caldicellulosiruptor saccharolyticus
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Panax ginseng
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Leuconostoc sp.
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium longum H-1
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rd + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose
?
3.2.1.B23
ginsenoside Re + H2O
753334
Mucilaginibacter sp. QM49
ginsenoside Rg2 + D-glucose
?
3.2.1.B23
ginsenoside Rg1 + H2O
753334
Mucilaginibacter sp. QM49
ginsenoside Rh1 + D-glucose
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Thermus thermophilus
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Trichoderma viride
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Aspergillus sp.
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Bifidobacterium longum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Lissachatina fulica
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Passalora fulva
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Pseudothermotoga thermarum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Flavobacterium johnsoniae
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium breve
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Trichoderma viride
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Caldicellulosiruptor saccharolyticus
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium longum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium choerinum
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Aspergillus niger
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Pseudonocardia sp.
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Rhizobium sp.
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Microbacterium esteraromaticum
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Mucilaginibacter sp. QM49
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Bifidobacterium longum H-1
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium longum H-1
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Pseudothermotoga thermarum DSM 5069T
?
?
3.2.1.191
ginsenoside Rb1 + H2O
753334
Sphingomonas sp.
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
753334
Sphingopyxis alaskensis
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Terrabacter ginsenosidimutans
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Esteya vermicola
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Esteya vermicola CNU120806
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
753334
Sphingomonas sp.
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
753334
Sphingopyxis alaskensis
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
via ginsenoside C-O
753334
Terrabacter ginsenosidimutans
ginsenoside C-Y + 2 D-glucose
?
3.2.1.191
ginsenoside Rb3 + H2O
via ginsenoside C-Mx1
753334
Terrabacter ginsenosidimutans
ginsenoside C-Mx + 2 D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
753334
Sphingomonas sp.
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
753334
Sphingopyxis alaskensis
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
via ginsenoside C-Mc1
753334
Terrabacter ginsenosidimutans
ginsenoside C-Mc + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenoside F2
753334
Esteya vermicola
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Terrabacter ginsenosidimutans
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Esteya vermicola
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenoside F2
753334
Esteya vermicola CNU120806
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Esteya vermicola CNU120806
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
753334
Sphingomonas sp.
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
753334
Sphingopyxis alaskensis
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium sp.
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium proliferatum
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Panax ginseng
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Sphingopyxis alaskensis
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium proliferatum ECU2042
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
via ginsenoside Rh2
753334
Terrabacter ginsenosidimutans
protopanaxadiol aglycone + 2 D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
via ginsenoside Rh2, hydrolysis of the inner glucose at C-3
753334
Aspergillus niger
protopanaxadiol aglycone + 2 D-glucose
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Aspergillus niger
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium sp.
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Sphingomonas sp.
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium proliferatum
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Panax ginseng
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Terrabacter ginsenosidimutans
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Sphingopyxis alaskensis
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Esteya vermicola
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Aspergillus niger
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium sp.
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Sphingomonas sp.
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium proliferatum
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Panax ginseng
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Terrabacter ginsenosidimutans
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Esteya vermicola
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides. beta-Glucosidase from Sphingopyxis alaskensis hydrolyzes only the outer glucose at C-3 in ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to product G17, C-O, C-Mc1, F2 and Rh2, respectively, without further hydrolysis
753334
Sphingopyxis alaskensis
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Esteya vermicola CNU120806
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Esteya vermicola CNU120806
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium proliferatum ECU2042
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium proliferatum ECU2042
?
?
3.2.1.193
ginsenoside F2 + H2O
753334
Sphingomonas leidyi
ginsenoside C-K + D-glucose
?
3.2.1.193
ginsenoside F2 + H2O
753334
Aspergillus oryzae
ginsenoside C-K + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Leuconostoc citreum
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Sulfolobus acidocaldarius
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Leuconostoc mesenteroides
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Lactiplantibacillus pentosus
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Microbacterium esteraromaticum
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Fusobacterium sp.
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Companilactobacillus paralimentarius
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Sphingomonas leidyi
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Lactiplantibacillus pentosus 6105
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Leuconostoc mesenteroides DC102
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Leuconostoc citreum LH1
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger g.848
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Aspergillus oryzae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Intrasporangium sp.
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Globisporangium irregulare
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Nocardioides panaciterrulae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Sphingomonas leidyi
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Intrasporangium sp. GS603
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Byssochlamys spectabilis
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Citrus limon
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 3 D-glucose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Sulfolobus acidocaldarius
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Microbacterium esteraromaticum
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb3 + H2O
via ginsenoside F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rb3 + H2O
via ginsenoside F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Nocardioides panaciterrulae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rd + H2O
753334
Byssochlamys spectabilis
ginsenoside Rg3 + D-glucose
?
3.2.1.193
ginsenoside Rd + H2O
753334
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + D-glucose
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus niger
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Byssochlamys spectabilis
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Sulfolobus acidocaldarius
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc mesenteroides
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Lactiplantibacillus pentosus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Saccharolobus solfataricus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus oryzae
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Microbacterium esteraromaticum
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Citrus limon
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc citreum
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Fusobacterium sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Pseudarthrobacter chlorophenolicus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Intrasporangium sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Globisporangium irregulare
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Nocardioides panaciterrulae
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Companilactobacillus paralimentarius
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Sphingomonas leidyi
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Byssochlamys spectabilis 229-7
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Lactiplantibacillus pentosus 6105
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Intrasporangium sp. GS603
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc mesenteroides DC102
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc citreum LH1
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus niger g.848
?
?
3.2.1.194
ginsenoside R1 + H2O
753334
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Pyrococcus furiosus
ginsenoside Rg1 + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Penicillium decumbens
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Aspergillus niger
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Pyrococcus furiosus
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Aspergillus sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Penicillium decumbens
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Penicillium decumbens
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Fusarium subglutinans
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Penicillium sclerotiorum
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Sanguibacter keddieii
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg2 + 2 H2O
753334
Penicillium decumbens
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Pyrococcus furiosus
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Absidia sp. (in: Fungi)
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Aspergillus sp.
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rh1 + H2O
753334
Penicillium decumbens
protopanaxatriol + D-glucose
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Aspergillus niger
753334
Aspergillus niger
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
753334
Absidia sp. (in: Fungi)
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion was performed using b-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Thermoanaerobacterium thermosaccharolyticum
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Penicillium decumbens
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Fusarium subglutinans
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Penicillium sclerotiorum
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Sanguibacter keddieii
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
753334
Aspergillus sp.
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion is performed using beta-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides. beta-Gglycosidase from Pyrococcus furiosus shows broad substrate specificity that hydrolyzes the outer residue glucose and rhamnose and xylose at C-6
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides. beta-Xylosidase from Thermoanaerobacterium thermosaccharolyticum converts notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1 by selectively hydrolyzing only the outer xylose at C-6
753334
Thermoanaerobacterium thermosaccharolyticum
?
?
3.2.1.194
notoginsenoside R1 + H2O
753334
Pyrococcus furiosus
ginsenoside Rg1 + D-xylose
?
3.2.1.194
notoginsenoside R1 + H2O
753334
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rg1 + D-xylose
?
3.2.1.195
ginsenoside Re + H2O
753334
Penicillium sp.
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Re + H2O
753334
Actinosynnema mirum
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Rg1 + H2O
via ginsenoside Rh1
753334
Penicillium sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.195
ginsenoside Rg1 + H2O
via ginsenoside Rh1
753334
Actinosynnema mirum
protopanaxatriol + 2 D-glucose
?
3.2.1.195
additional information
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
753334
Penicillium sp.
?
?
3.2.1.195
additional information
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
753334
Actinosynnema mirum
?
?
3.2.1.B23
ginsenoside C-K + H2O
Rhizobium sp.
protopanaxadiol + D-glucose
?
3.2.1.B23
ginsenoside C-O + H2O
Bifidobacterium choerinum
ginsenoside F2 + L-arabinopyranose
?
3.2.1.B23
ginsenoside G17 + H2O
Thermus thermophilus
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Bifidobacterium longum
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Flavobacterium johnsoniae
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
Bifidobacterium longum H-1
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G75 + H2O
Thermus thermophilus
ginsenoside C-K + D-glucose
?
3.2.1.B23
ginsenoside Mc + H2O
Caldicellulosiruptor saccharolyticus
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc + H2O
Rhodanobacter ginsenosidimutans
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc1 + H2O
Rhodanobacter ginsenosidimutans
ginsenoside F2 + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Thermus thermophilus
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Trichoderma viride
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Aspergillus sp.
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Bifidobacterium longum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Lissachatina fulica
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Passalora fulva
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudothermotoga thermarum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Flavobacterium johnsoniae
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Aspergillus niger
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudonocardia sp.
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Microbacterium esteraromaticum
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Bifidobacterium longum H-1
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
Pseudothermotoga thermarum DSM 5069T
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Bifidobacterium choerinum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
Microbacterium esteraromaticum
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.B23
ginsenoside Rb3 + H2O
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose + D-xylose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium breve
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Caldicellulosiruptor saccharolyticus
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Panax ginseng
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Leuconostoc sp.
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Rhodanobacter ginsenosidimutans
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
Bifidobacterium longum H-1
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rd + H2O
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose
?
3.2.1.B23
ginsenoside Re + H2O
Mucilaginibacter sp. QM49
ginsenoside Rg2 + D-glucose
?
3.2.1.B23
ginsenoside Rg1 + H2O
Mucilaginibacter sp. QM49
ginsenoside Rh1 + D-glucose
?
3.2.1.B23
additional information
Thermus thermophilus
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Trichoderma viride
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Aspergillus sp.
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium longum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Lissachatina fulica
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Passalora fulva
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Pseudothermotoga thermarum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Flavobacterium johnsoniae
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium breve
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Trichoderma viride
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Caldicellulosiruptor saccharolyticus
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium longum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium choerinum
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Bifidobacterium longum H-1
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.B23
additional information
Bifidobacterium longum H-1
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
?
?
3.2.1.B23
additional information
Pseudothermotoga thermarum DSM 5069T
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
?
?
3.2.1.191
ginsenoside Rb1 + H2O
Sphingomonas sp.
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Sphingopyxis alaskensis
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Esteya vermicola
via ginsenoside G17
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
Esteya vermicola CNU120806
via ginsenoside G17
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
Sphingomonas sp.
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
Sphingopyxis alaskensis
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
Sphingomonas sp.
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
Sphingopyxis alaskensis
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Esteya vermicola
via ginsenosside F2
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Sphingomonas sp.
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Sphingopyxis alaskensis
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
Esteya vermicola CNU120806
via ginsenosside F2
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium sp.
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium proliferatum
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Panax ginseng
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Sphingopyxis alaskensis
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
Fusarium proliferatum ECU2042
ginsenoside Rh2 + D-glucose
?
3.2.1.191
additional information
Aspergillus niger
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium sp.
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Sphingomonas sp.
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium proliferatum
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Panax ginseng
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Terrabacter ginsenosidimutans
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Sphingopyxis alaskensis
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Esteya vermicola
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Esteya vermicola CNU120806
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.191
additional information
Fusarium proliferatum ECU2042
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
?
?
3.2.1.193
ginsenoside F2 + H2O
Sphingomonas leidyi
ginsenoside C-K + D-glucose
?
3.2.1.193
ginsenoside F2 + H2O
Aspergillus oryzae
ginsenoside C-K + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc citreum
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sulfolobus acidocaldarius
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc mesenteroides
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Lactiplantibacillus pentosus
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Microbacterium esteraromaticum
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Fusobacterium sp.
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Companilactobacillus paralimentarius
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sphingomonas leidyi
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus niger
via ginsenosides Rd and F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus oryzae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Intrasporangium sp.
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Globisporangium irregulare
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Nocardioides panaciterrulae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Sphingomonas leidyi
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Byssochlamys spectabilis
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Citrus limon
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Lactiplantibacillus pentosus 6105
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Intrasporangium sp. GS603
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc mesenteroides DC102
via ginsenosides F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Leuconostoc citreum LH1
via ginsenoside F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
Aspergillus niger g.848
via ginsenosides Rd and F2
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Sulfolobus acidocaldarius
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Microbacterium esteraromaticum
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus niger
via ginsenosides Rd and F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
Aspergillus niger g.848
via ginsenosides Rd and F2
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb3 + H2O
Aspergillus niger
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rb3 + H2O
Aspergillus niger g.848
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Nocardioides panaciterrulae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus niger
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Saccharolobus solfataricus
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus sp.
via ginsenoside F2
ginsenoside Rh2 + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
Aspergillus niger g.848
via ginsenoside F2
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rd + H2O
Byssochlamys spectabilis
ginsenoside Rg3 + D-glucose
?
3.2.1.193
ginsenoside Rd + H2O
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + D-glucose
?
3.2.1.193
additional information
Aspergillus niger
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Byssochlamys spectabilis
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Sulfolobus acidocaldarius
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc mesenteroides
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Lactiplantibacillus pentosus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Saccharolobus solfataricus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus oryzae
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Microbacterium esteraromaticum
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Citrus limon
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc citreum
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Fusobacterium sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Pseudarthrobacter chlorophenolicus
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Intrasporangium sp.
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Globisporangium irregulare
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Nocardioides panaciterrulae
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Companilactobacillus paralimentarius
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Sphingomonas leidyi
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Byssochlamys spectabilis 229-7
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Lactiplantibacillus pentosus 6105
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Intrasporangium sp. GS603
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc mesenteroides DC102
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Leuconostoc citreum LH1
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.193
additional information
Aspergillus niger g.848
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
?
?
3.2.1.194
ginsenoside R1 + H2O
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Pyrococcus furiosus
ginsenoside Rg1 + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
Penicillium decumbens
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rf + H2O
Aspergillus niger
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Pyrococcus furiosus
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Aspergillus sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
Penicillium decumbens
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Penicillium decumbens
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Fusarium subglutinans
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Penicillium sclerotiorum
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
Sanguibacter keddieii
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg2 + 2 H2O
Penicillium decumbens
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Pyrococcus furiosus
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Absidia sp. (in: Fungi)
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
Aspergillus sp.
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rh1 + H2O
Penicillium decumbens
protopanaxatriol + D-glucose
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
?
?
3.2.1.194
additional information
Aspergillus niger
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Aspergillus niger
?
?
3.2.1.194
additional information
Absidia sp. (in: Fungi)
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
?
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion was performed using b-glycosidase from Pyrococcus furiosus
?
?
3.2.1.194
additional information
Pyrococcus furiosus
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Thermoanaerobacterium thermosaccharolyticum
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Penicillium decumbens
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Fusarium subglutinans
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Penicillium sclerotiorum
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Sanguibacter keddieii
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
?
?
3.2.1.194
additional information
Aspergillus sp.
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
?
?
3.2.1.194
notoginsenoside R1 + H2O
Pyrococcus furiosus
ginsenoside Rg1 + D-xylose
?
3.2.1.194
notoginsenoside R1 + H2O
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rg1 + D-xylose
?
3.2.1.195
ginsenoside Re + H2O
Penicillium sp.
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Re + H2O
Actinosynnema mirum
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Rg1 + H2O
Penicillium sp.
via ginsenoside Rh1
protopanaxatriol + 2 D-glucose
?
3.2.1.195
ginsenoside Rg1 + H2O
Actinosynnema mirum
via ginsenoside Rh1
protopanaxatriol + 2 D-glucose
?
3.2.1.195
additional information
Penicillium sp.
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
?
?
3.2.1.195
additional information
Actinosynnema mirum
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
?
?
3.2.1.B23
ginsenoside C-K + H2O
753334
Rhizobium sp.
protopanaxadiol + D-glucose
?
3.2.1.B23
ginsenoside C-O + H2O
753334
Bifidobacterium choerinum
ginsenoside F2 + L-arabinopyranose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Thermus thermophilus
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Bifidobacterium longum
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Flavobacterium johnsoniae
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G17 + H2O
753334
Bifidobacterium longum H-1
ginsenoside F2 + D-glucose
?
3.2.1.B23
ginsenoside G75 + H2O
753334
Thermus thermophilus
ginsenoside C-K + D-glucose
?
3.2.1.B23
ginsenoside Mc + H2O
753334
Caldicellulosiruptor saccharolyticus
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside C-K + L-arabinofuranose
?
3.2.1.B23
ginsenoside Mc1 + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside F2 + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Thermus thermophilus
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Trichoderma viride
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Aspergillus sp.
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Bifidobacterium longum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Lissachatina fulica
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Passalora fulva
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudothermotoga thermarum
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Flavobacterium johnsoniae
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Bifidobacterium longum H-1
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudothermotoga thermarum DSM 5069T
ginsenoside Rd + D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Aspergillus niger
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb1 + H2O
753334
Microbacterium esteraromaticum
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Bifidobacterium choerinum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rb2 + H2O
753334
Microbacterium esteraromaticum
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.B23
ginsenoside Rb3 + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose + D-xylose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium breve
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Trichoderma viride
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Caldicellulosiruptor saccharolyticus
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium longum
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Panax ginseng
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Leuconostoc sp.
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Rhodanobacter ginsenosidimutans
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rc + H2O
753334
Bifidobacterium longum H-1
ginsenoside Rd + L-arabinofuranose
?
3.2.1.B23
ginsenoside Rd + H2O
753334
Pseudonocardia sp.
ginsenoside Rg3 + D-glucose
?
3.2.1.B23
ginsenoside Re + H2O
753334
Mucilaginibacter sp. QM49
ginsenoside Rg2 + D-glucose
?
3.2.1.B23
ginsenoside Rg1 + H2O
753334
Mucilaginibacter sp. QM49
ginsenoside Rh1 + D-glucose
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Thermus thermophilus
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Trichoderma viride
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Aspergillus sp.
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Bifidobacterium longum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Lissachatina fulica
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Passalora fulva
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Pseudothermotoga thermarum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Flavobacterium johnsoniae
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium breve
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Trichoderma viride
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Caldicellulosiruptor saccharolyticus
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium longum
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium choerinum
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Aspergillus niger
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Pseudonocardia sp.
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Rhizobium sp.
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Microbacterium esteraromaticum
?
?
3.2.1.B23
additional information
hydrolysis of the C-20 inner Glc
753334
Mucilaginibacter sp. QM49
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Bifidobacterium longum H-1
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
753334
Bifidobacterium longum H-1
?
?
3.2.1.B23
additional information
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1. Ginsenosidase type II-i-1 catalyze hydrolysis of C-20 outer Glc (hydrolysis pattern A-1)
753334
Pseudothermotoga thermarum DSM 5069T
?
?
3.2.1.191
ginsenoside Rb1 + H2O
753334
Sphingomonas sp.
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
753334
Sphingopyxis alaskensis
ginsenoside G17 + D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Terrabacter ginsenosidimutans
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Esteya vermicola
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb1 + H2O
via ginsenoside G17
753334
Esteya vermicola CNU120806
ginsenoside G75 + 2 D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
753334
Sphingomonas sp.
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
753334
Sphingopyxis alaskensis
ginsenoside C-O + D-glucose
?
3.2.1.191
ginsenoside Rb2 + H2O
via ginsenoside C-O
753334
Terrabacter ginsenosidimutans
ginsenoside C-Y + 2 D-glucose
?
3.2.1.191
ginsenoside Rb3 + H2O
via ginsenoside C-Mx1
753334
Terrabacter ginsenosidimutans
ginsenoside C-Mx + 2 D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
753334
Sphingomonas sp.
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
753334
Sphingopyxis alaskensis
ginsenoside C-Mc1 + D-glucose
?
3.2.1.191
ginsenoside Rc + H2O
via ginsenoside C-Mc1
753334
Terrabacter ginsenosidimutans
ginsenoside C-Mc + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenoside F2
753334
Esteya vermicola
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Terrabacter ginsenosidimutans
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Esteya vermicola
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenoside F2
753334
Esteya vermicola CNU120806
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
via ginsenosside F2
753334
Esteya vermicola CNU120806
ginsenoside C-K + 2 D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
753334
Sphingomonas sp.
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rd + H2O
753334
Sphingopyxis alaskensis
ginsenoside F2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium sp.
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium proliferatum
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Panax ginseng
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Sphingopyxis alaskensis
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
753334
Fusarium proliferatum ECU2042
ginsenoside Rh2 + D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
via ginsenoside Rh2
753334
Terrabacter ginsenosidimutans
protopanaxadiol aglycone + 2 D-glucose
?
3.2.1.191
ginsenoside Rg3 + H2O
via ginsenoside Rh2, hydrolysis of the inner glucose at C-3
753334
Aspergillus niger
protopanaxadiol aglycone + 2 D-glucose
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Aspergillus niger
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium sp.
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Sphingomonas sp.
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium proliferatum
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Panax ginseng
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Terrabacter ginsenosidimutans
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Sphingopyxis alaskensis
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Esteya vermicola
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Aspergillus niger
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium sp.
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Sphingomonas sp.
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium proliferatum
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Panax ginseng
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Terrabacter ginsenosidimutans
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Esteya vermicola
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides. beta-Glucosidase from Sphingopyxis alaskensis hydrolyzes only the outer glucose at C-3 in ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to product G17, C-O, C-Mc1, F2 and Rh2, respectively, without further hydrolysis
753334
Sphingopyxis alaskensis
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Esteya vermicola CNU120806
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Esteya vermicola CNU120806
?
?
3.2.1.191
additional information
ginsenosidase type III are classified into types III-i and III-ii, which hydrolyze the outer glucose and inner glucose linked to C-3 in the PPD-type ginsenosides, respectively. Ginsenosidase type III-i converts ginsenosides Rb1, Rb2, Rc, Rd and Rg3 to G17, C-O, C-Mc1, F2 and Rh2, respectively, by hydrolyzing only the outer glucose linked to C-3 in the PPD-type ginsenosides
753334
Fusarium proliferatum ECU2042
?
?
3.2.1.191
additional information
ginsenosidase type III-i catalyzes the hydrolysis of only C-3 outer glucose in PPD-type gindenosides. Ginsenosidase type III-ii catalyzes the hydrolysis of outer and inner, or only inner glucose in PPD-type ginsenosides
753334
Fusarium proliferatum ECU2042
?
?
3.2.1.193
ginsenoside F2 + H2O
753334
Sphingomonas leidyi
ginsenoside C-K + D-glucose
?
3.2.1.193
ginsenoside F2 + H2O
753334
Aspergillus oryzae
ginsenoside C-K + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Leuconostoc citreum
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Sulfolobus acidocaldarius
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Leuconostoc mesenteroides
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Lactiplantibacillus pentosus
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Microbacterium esteraromaticum
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Fusobacterium sp.
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Companilactobacillus paralimentarius
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Sphingomonas leidyi
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Lactiplantibacillus pentosus 6105
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides F2
753334
Leuconostoc mesenteroides DC102
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Leuconostoc citreum LH1
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger g.848
ginsenoside C-K + 3 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Aspergillus oryzae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Intrasporangium sp.
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Globisporangium irregulare
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Nocardioides panaciterrulae
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Sphingomonas leidyi
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Intrasporangium sp. GS603
ginsenoside F2 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Byssochlamys spectabilis
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Citrus limon
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
753334
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + 2 D-glucose
?
3.2.1.193
ginsenoside Rb1 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 3 D-glucose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Sulfolobus acidocaldarius
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Microbacterium esteraromaticum
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenosides Rd and F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
753334
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb2 + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 2 D-glucose + L-arabinopyranose
?
3.2.1.193
ginsenoside Rb3 + H2O
via ginsenoside F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rb3 + H2O
via ginsenoside F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + xylose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Aspergillus oryzae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Pseudarthrobacter chlorophenolicus
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Globisporangium irregulare
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Nocardioides panaciterrulae
ginsenoside F2 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus niger
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Saccharolobus solfataricus
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus niger g.848
ginsenoside C-K + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
753334
Citrus limon
ginsenoside Rg3 + D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rc + H2O
via ginsenoside F2
753334
Aspergillus sp.
ginsenoside Rh2 + 2 D-glucose + L-arabinofuranose
?
3.2.1.193
ginsenoside Rd + H2O
753334
Byssochlamys spectabilis
ginsenoside Rg3 + D-glucose
?
3.2.1.193
ginsenoside Rd + H2O
753334
Byssochlamys spectabilis 229-7
ginsenoside Rg3 + D-glucose
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus niger
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Byssochlamys spectabilis
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Sulfolobus acidocaldarius
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc mesenteroides
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Lactiplantibacillus pentosus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Saccharolobus solfataricus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus oryzae
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Microbacterium esteraromaticum
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Citrus limon
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc citreum
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Fusobacterium sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Pseudarthrobacter chlorophenolicus
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Intrasporangium sp.
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Globisporangium irregulare
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Nocardioides panaciterrulae
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Companilactobacillus paralimentarius
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Sphingomonas leidyi
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Byssochlamys spectabilis 229-7
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Lactiplantibacillus pentosus 6105
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Intrasporangium sp. GS603
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc mesenteroides DC102
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Leuconostoc citreum LH1
?
?
3.2.1.193
additional information
ginsenosidase type I enzymes simultaneously hydrolyze the sugars linked to C-20 and C-3 in the PPD-type ginsenosides and have broad hydrolysis patterns of A, B, C and D
753334
Aspergillus niger g.848
?
?
3.2.1.194
ginsenoside R1 + H2O
753334
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Pyrococcus furiosus
ginsenoside Rg1 + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Aspergillus sp.
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Re + H2O
753334
Penicillium decumbens
ginsenoside F1 + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Aspergillus niger
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Pyrococcus furiosus
ginsenoside Rh1 + D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Aspergillus sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rf + H2O
753334
Penicillium decumbens
protopanaxatriol + 2 D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Penicillium decumbens
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Fusarium subglutinans
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Penicillium sclerotiorum
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg1 + H2O
753334
Sanguibacter keddieii
ginsenoside F1 + D-glucose
?
3.2.1.194
ginsenoside Rg2 + 2 H2O
753334
Penicillium decumbens
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Pyrococcus furiosus
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Absidia sp. (in: Fungi)
ginsenoside Rh1 + L-rhamnose
?
3.2.1.194
ginsenoside Rg2 + H2O
753334
Aspergillus sp.
protopanaxatriol + D-glucose + L-rhamnose
?
3.2.1.194
ginsenoside Rh1 + H2O
753334
Penicillium decumbens
protopanaxatriol + D-glucose
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Aspergillus niger
753334
Aspergillus niger
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
753334
Absidia sp. (in: Fungi)
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion was performed using b-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Thermoanaerobacterium thermosaccharolyticum
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Penicillium decumbens
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Fusarium subglutinans
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Penicillium sclerotiorum
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
753334
Sanguibacter keddieii
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
753334
Aspergillus sp.
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1. This conversion has been conducted by beta-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2. This conversion is performed using beta-glycosidase from Pyrococcus furiosus
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides. beta-Gglycosidase from Pyrococcus furiosus shows broad substrate specificity that hydrolyzes the outer residue glucose and rhamnose and xylose at C-6
753334
Pyrococcus furiosus
?
?
3.2.1.194
additional information
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides. beta-Xylosidase from Thermoanaerobacterium thermosaccharolyticum converts notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1 by selectively hydrolyzing only the outer xylose at C-6
753334
Thermoanaerobacterium thermosaccharolyticum
?
?
3.2.1.194
notoginsenoside R1 + H2O
753334
Pyrococcus furiosus
ginsenoside Rg1 + D-xylose
?
3.2.1.194
notoginsenoside R1 + H2O
753334
Thermoanaerobacterium thermosaccharolyticum
ginsenoside Rg1 + D-xylose
?
3.2.1.195
ginsenoside Re + H2O
753334
Penicillium sp.
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Re + H2O
753334
Actinosynnema mirum
ginsenoside Rh1 + D-glucose + L-rhamnose
?
3.2.1.195
ginsenoside Rg1 + H2O
via ginsenoside Rh1
753334
Penicillium sp.
protopanaxatriol + 2 D-glucose
?
3.2.1.195
ginsenoside Rg1 + H2O
via ginsenoside Rh1
753334
Actinosynnema mirum
protopanaxatriol + 2 D-glucose
?
3.2.1.195
additional information
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
753334
Penicillium sp.
?
?
3.2.1.195
additional information
ginsenosidase type V enzymes hydrolyze the sugars linked to C-20 and C-6 in the PPD-type ginsenosides with the hydrolysis patterns of B, E and F. Crude enzyme from Penicillium sp. and beta-glucosidase from Actinosynnema mirum convert ginsenosides Re and Rg1 to Rh1 and APPT, respectively
753334
Actinosynnema mirum
?
?
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Thermus thermophilus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pseudothermotoga thermarum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 2, GH2
Microbacterium esteraromaticum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Pseudonocardia sp.
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Microbacterium esteraromaticum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Bifidobacterium longum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Flavobacterium johnsoniae
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Mucilaginibacter sp. QM49
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 42, GH42
Caldicellulosiruptor saccharolyticus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Caldicellulosiruptor saccharolyticus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Bifidobacterium longum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Leuconostoc sp.
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Rhodanobacter ginsenosidimutans
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Caldicellulosiruptor saccharolyticus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Panax ginseng
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Leuconostoc sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Rhodanobacter ginsenosidimutans
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium breve
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Caldicellulosiruptor saccharolyticus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium choerinum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Thermus thermophilus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Aspergillus sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Lissachatina fulica
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Passalora fulva
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Pseudothermotoga thermarum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Flavobacterium johnsoniae
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Aspergillus niger
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Pseudonocardia sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Rhizobium sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Microbacterium esteraromaticum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Mucilaginibacter sp. QM49
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sphingomonas sp.
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sphingopyxis alaskensis
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus niger
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Fusarium sp.
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Terrabacter ginsenosidimutans
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Esteya vermicola
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sulfolobus acidocaldarius
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Saccharolobus solfataricus
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Leuconostoc citreum
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pseudarthrobacter chlorophenolicus
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Microbacterium esteraromaticum
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pyrococcus furiosus
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 39, GH39
Thermoanaerobacterium thermosaccharolyticum
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus niger
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus sp.
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Sanguibacter keddieii
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 78, GH78
Absidia sp. (in: Fungi)
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
Aspergillus niger
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
Absidia sp. (in: Fungi)
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Thermoanaerobacterium thermosaccharolyticum
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Penicillium decumbens
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Fusarium subglutinans
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Penicillium sclerotiorum
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Sanguibacter keddieii
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
Aspergillus sp.
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Thermus thermophilus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pseudothermotoga thermarum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 2, GH2
Microbacterium esteraromaticum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Pseudonocardia sp.
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Microbacterium esteraromaticum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Bifidobacterium longum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Flavobacterium johnsoniae
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Mucilaginibacter sp. QM49
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 42, GH42
Caldicellulosiruptor saccharolyticus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Caldicellulosiruptor saccharolyticus
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Bifidobacterium longum
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Leuconostoc sp.
3.2.1.B23
evolution
the enzyme belongs to the glycosyl hydrolase family 51, GH51
Rhodanobacter ginsenosidimutans
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Caldicellulosiruptor saccharolyticus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Panax ginseng
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Leuconostoc sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2
Rhodanobacter ginsenosidimutans
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium breve
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Caldicellulosiruptor saccharolyticus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-i-2 enzymes convert ginsenosides Rb2, C-O and C-Y to ginsenosides Rd, F2 and C-K as final products without further hydrolysis, respectively, through the hydrolysis of the outer arabinopyranose linked to C-20 with the hydrolysis pattern of A-2 (Rb2->C-O->C-Y)
Bifidobacterium choerinum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Thermus thermophilus
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Trichoderma viride
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Aspergillus sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Bifidobacterium longum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Lissachatina fulica
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Passalora fulva
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Pseudothermotoga thermarum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-2. Ginsenosidase type II-i-1 enzymes convert ginsenosides Rb1, G17 and G75 to ginsenosides Rd, F2 and CK as final products, respectively, by hydrolyzing only the outer glucose linked to C-20 but not the inner glucose linked to C-20 with the hydrolysis pattern of A-1 (Rb1->G17->G75). Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively, with the hydrolysis pattern of B (Rd->F2->C-K or Rg3->Rh2->APPD). Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides with 4 different hydrolysis patterns
Flavobacterium johnsoniae
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Aspergillus niger
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Pseudonocardia sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Rhizobium sp.
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Microbacterium esteraromaticum
3.2.1.B23
physiological function
ginsenosidase type II enzymes hydrolyze the sugars linked to C-20 in the PPD- and PPT-type ginsenosides, respectively. Type II enzymes are divided into types II-i-1, II-i-2, II-i-3, II-i-4 and II-ii. Ginsenosides Rd, F2, C-K, Re, Rg1, F1 and notoginsenoside R1 are converted to Rg3, Rh2, APPD, Rg2, Rh1, APPT and notoginsenoside R2 without further hydrolysis, respectively, by ginsenosidase type II-ii enzymes through the hydrolysis of the inner glucose at C-20 but not the sugar residues linked to C-3 and C-6 in the PPD- and PPT-type ginsenosides, respectively. Ginsenosidase type II-ii enzymes also hydrolyze the outer sugar, including glucose, arabinopyranose or arabinofuranose linked to C-20 in the PPD-type ginsenosides
Mucilaginibacter sp. QM49
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sphingomonas sp.
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sphingopyxis alaskensis
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus niger
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Fusarium sp.
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Terrabacter ginsenosidimutans
3.2.1.191
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Esteya vermicola
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Sulfolobus acidocaldarius
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Saccharolobus solfataricus
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Leuconostoc citreum
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pseudarthrobacter chlorophenolicus
3.2.1.193
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Microbacterium esteraromaticum
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 1, GH1
Pyrococcus furiosus
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 39, GH39
Thermoanaerobacterium thermosaccharolyticum
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus niger
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Aspergillus sp.
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 3, GH3
Sanguibacter keddieii
3.2.1.194
evolution
the enzyme belongs to the glycosyl hydrolase family 78, GH78
Absidia sp. (in: Fungi)
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
Aspergillus niger
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-1 enzymes convert ginsenoside Rf to Rh1 by the hydrolysis of only the outer glucose linked to C-20 and not the inner glucose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-1
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-2 enzymes convert ginsenosides Re and Rg2 to ginsenosides Rg1 and Rh1, respectively, by hydrolyzing only the outer rhamnose linked to C-6 in the PPT-type ginsenosides with the hydrolysis pattern of E-2
Absidia sp. (in: Fungi)
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Pyrococcus furiosus
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Thermoanaerobacterium thermosaccharolyticum
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Penicillium decumbens
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Fusarium subglutinans
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Penicillium sclerotiorum
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-i-3 enzymes convert notoginsenosides R1 and R2 to ginsenosides Rg1 and Rh1, respectively, with the hydrolysis pattern of E-3 through the hydrolysis of the outer xylose linked to C-6 without further hydrolysis in the PPT-type ginsenosides
Sanguibacter keddieii
3.2.1.194
physiological function
ginsenosidase type IV hydrolyzes the sugars linked to C-6 in the PPT-type ginsenosides. Ginsenosidase type IV enzymes are subdivided into types IV-i-1, IV-i-2, IV-i-3, and IV-ii. Ginsenosidase type IV-ii enzymes convert ginsenosides Rg1 and Rh1, containing only the inner glucose without the outer sugar at C-6, are converted to ginsenosides F1 and aglycone protopanaxatriol (APPT), respectively, by hydrolyzing the inner glucose linked to C-6 but not the glucose linked to C-20 in the PPT-type ginsenosides with the hydrolysis pattern of F. Ginsenosidase type IV-ii enzymes also hydrolyze the outer glucose of ginsenoside Rf, which has the outer and inner glucose at C-6 with the hydrolysis pattern of E-1; the outer rhamnose of ginsenosides Re and Rg2, which have the outer rhamnose and inner glucose at C-6 with the hydrolysis attern of E-2, and the outer xylose of notoginsenosides R1 and R2, which contain the outer xylose and inner glucose at C-6 with the hydrolysis pattern of E-3
Aspergillus sp.