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Literature summary extracted from

  • De Santa, F.; Totaro, M.G.; Prosperini, E.; Notarbartolo, S.; Testa, G.; Natoli, G.
    The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing (2007), Cell, 130, 1083-1094 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.68 nucleus exclusivley nuclear localization Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.68 Fe2+ required Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.68 Mus musculus Q5NCY0 isoform Jmjd3
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.68 macrophage expressed in macrophages in response to bacterial products and inflammatory cytokines Mus musculus
-
1.14.11.68 RAW-264.7 cell
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 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.68 [histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
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 Mus musculus [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.68 JMJD3
-
 Mus musculus
1.14.11.68 KDM6B
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.11.68 physiological function Jmjd3 is expressed in macrophages in response to bacterial products and inflammatory cytokines. Jmjd3 binds PcG target genes and regulates their H3K27me3 levels and transcriptional activity, the activation of Jmjd3 requires NF-kappaB Mus musculus