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Literature summary extracted from

  • Whetstine, J.R.; Nottke, A.; Lan, F.; Huarte, M.; Smolikov, S.; Chen, Z.; Spooner, E.; Li, E.; Zhang, G.; Colaiacovo, M.; Shi, Y.
    Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases (2006), Cell, 125, 467-481 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.69 Fe2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.69 a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens
-
 a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.69 additional information Homo sapiens JMJD2A demethylates trimethylated histone K9/K36 to di- but not mono- or unmethylated products, i.e. JMJD2A also catalyzes the reactions of EC 1.14.11.66, H3K9 trimethyl demethylase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.69 Caenorhabditis elegans Q9U297
-
-
1.14.11.69 Homo sapiens O75164
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.69 a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.69 additional information JMJD2A demethylates trimethylated histone K9/K36 to di- but not mono- or unmethylated products, i.e. JMJD2A also catalyzes the reactions of EC 1.14.11.66, H3K9 trimethyl demethylase Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.69 JMJD-2
-
 Caenorhabditis elegans
1.14.11.69 JMJD2A
-
 Homo sapiens
1.14.11.69 KDM4
-
 Caenorhabditis elegans
1.14.11.69 KDM4A
-
 Homo sapiens
1.14.11.69 lysine-specific demethylase 4A
-
 Homo sapiens
1.14.11.69 lysine-specific demethylase 4A
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
1.14.11.69 physiological function overexpression of JMJD2A reduces H3-K9/K36 trimethylation levels in cultured cells Homo sapiens
1.14.11.69 physiological function RNAi depletion results in an increase in general trimethylation of H3-K9 and localizes H3-K36Me3 levels on meiotic chromosomes and triggers p53-dependent germline apoptosis Caenorhabditis elegans