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Literature summary extracted from
- Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma implications for therapy (2009), Cancer Res., 69, 2065-2071 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.65 | gene lsd1, real-time reverse transcription-PCR expression enzyme analysis | Homo sapiens |
| 1.14.99.66 | gene lsd1, real-time reverse transcription-PCR expression enzyme analysis | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.11.65 | additional information | small interfering RNA-mediated knockdown of LSD1 | Homo sapiens |
| 1.14.99.66 | additional information | small interfering RNA-mediated knockdown of LSD1 | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.65 | additional information | small molecule inhibitors of LSD1 inhibit xenograft tumor growth | Homo sapiens | |
| 1.14.11.65 | tranylcypromine | - |
Homo sapiens |  |
| 1.14.99.66 | additional information | small molecule inhibitors of LSD1 inhibit xenograft tumor growth | Homo sapiens | |
| 1.14.99.66 | tranylcypromine | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.11.65 | nucleus | - |
Homo sapiens | 5634 | - |
| 1.14.99.66 | nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.65 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.65 | [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.99.66 | [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.65 | Homo sapiens | O60341 | - |
- |
| 1.14.99.66 | Homo sapiens | O60341 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.65 | neuroblastoma cell | lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma | Homo sapiens | - |
| 1.14.11.65 | SH-SY5Y cell | - |
Homo sapiens | - |
| 1.14.99.66 | neuroblastoma cell | lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma | Homo sapiens | - |
| 1.14.99.66 | SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.65 | additional information | LSD1 specificity and mechanism of action are complex-dependent | Homo sapiens | ? | - |
? | |
| 1.14.11.65 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.65 | [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.99.66 | additional information | LSD1 specificity and mechanism of action are complex-dependent | Homo sapiens | ? | - |
? | |
| 1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.99.66 | [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.65 | LSD1 | - |
Homo sapiens |
| 1.14.11.65 | lysine-specific demethylase 1 | - |
Homo sapiens |
| 1.14.99.66 | LSD1 | - |
Homo sapiens |
| 1.14.99.66 | lysine-specific demethylase 1 | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.11.65 | Homo sapiens | differentiation of neuroblastoma cells results in down-regulation of LSD1 | down |
| 1.14.99.66 | Homo sapiens | differentiation of neuroblastoma cells results in down-regulation of LSD1 | down |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.11.65 | malfunction | Differentiation of neuroblastoma cells results in down-regulation of LSD1. Small interfering RNA-mediated knockdown of LSD1 decreases cellular growth, induces expression of differentiation-associated genes, and increases target gene-specific H3K4 methylation. LSD1 inhibition using monoamine oxidase inhibitors results in an increase of global H3K4 methylation and growth inhibition of neuroblastoma cells in vitro. Small molecule inhibitors of LSD1 inhibit xenograft tumor growth | Homo sapiens |
| 1.14.11.65 | physiological function | LSD1 allows transcription factors or corepressor complexes to selectively initiate or repress transcription via demethylation of lysine residues 4 or 9 of histone 3, thereby controlling gene expression programs. LSD1 modulates tumor cell biology by demethylating monomethyl and dimethyl lysines 4 or 9 in histone H3. LSD1 specificity and mechanism of action are complex-dependent. Expression of the chromatin-modifying enzyme lysine-specific demethylase 1 in neuroblastoma is correlated with adverse outcome and inversely correlated with differentiation in neuroblastic tumors | Homo sapiens |
| 1.14.99.66 | malfunction | Differentiation of neuroblastoma cells results in down-regulation of LSD1. Small interfering RNA-mediated knockdown of LSD1 decreases cellular growth, induces expression of differentiation-associated genes, and increases target gene-specific H3K4 methylation. LSD1 inhibition using monoamine oxidase inhibitors results in an increase of global H3K4 methylation and growth inhibition of neuroblastoma cells in vitro. Small molecule inhibitors of LSD1 inhibit xenograft tumor growth | Homo sapiens |
| 1.14.99.66 | physiological function | LSD1 allows transcription factors or corepressor complexes to selectively initiate or repress transcription via demethylation of lysine residues 4 or 9 of histone 3, thereby controlling gene expression programs. LSD1 modulates tumor cell biology by demethylating monomethyl and dimethyl lysines 4 or 9 in histone H3. LSD1 specificity and mechanism of action are complex-dependent. Expression of the chromatin-modifying enzyme lysine-specific demethylase 1 in neuroblastoma is correlated with adverse outcome and inversely correlated with differentiation in neuroblastic tumors | Homo sapiens |
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