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Literature summary extracted from

  • Nakao, A.; Suzuki, H.; Ueno, H.; Iwasaki, H.; Setsuta, T.; Kashima, A.; Sunada, S.
    Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs (2015), Bioorg. Med. Chem., 23, 4952-4969 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.13.2.1 purified enzyme in complex with inhibitor N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(methylamino)ethyl]glycinamide hydrochloride, sitting drop vapor diffusion method, using a reservoir solution composed of 100 mM HEPES, pH 7.5, 13% w/v PEG 4000, 10% v/v 2-PrOH, and 0.5% v/v EtOAc, X-ray diffraction structure determination and analysis at 2.7 A resolution, modelling Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine MDL-28842 Homo sapiens
3.13.2.1 2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)amino]-2-oxoethyl]amino)-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
-
 Homo sapiens
3.13.2.1 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-cyclohexyl-N-methylacetamide
-
 Homo sapiens
3.13.2.1 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-methyl-N-(2-phenylethyl)acetamide
-
 Homo sapiens
3.13.2.1 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-methyl-N-[4-(2-nitrobenzene-1-sulfonyl)piperazin-1-yl]acetamide
-
 Homo sapiens
3.13.2.1 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-[[(2-fluorophenyl)methyl]amino]-2-oxoethyl)amino]-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
-
 Homo sapiens
3.13.2.1 2-[[5-chloro-2-(4-chlorophenoxy)phenyl][2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]amino]-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
-
 Homo sapiens
3.13.2.1 3'-deazaadenosine
-
 Homo sapiens
3.13.2.1 dihydroxypropyladenine DHPA Homo sapiens
3.13.2.1 additional information optimization of a series of S-adenosyl-L-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogues leads to very potent compounds Homo sapiens
3.13.2.1 N-benzyl-2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-methylacetamide
-
 Homo sapiens
3.13.2.1 N2-[2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl]-N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[2,3-dihydro-1H-inden-2-yl(ethyl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[methyl(piperidin-4-yl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[methyl(trans-4-phenylcyclohexyl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide inhibitor compound crystal structure determination and analysis, overview. The single crystal X-ray structure of 14n shows an intramolecular eight-membered ring hydrogen bond interaction Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(ethylamino)ethyl]glycinamide hydrochloride
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(methylamino)ethyl]glycinamide hydrochloride
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-piperidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(3-pyrrolidin-1-ylpropyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-methyl(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(dimethylamino)ethyl]glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroisoquinolin-2(1H)-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroquinolin-1(2H)-yl]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methy-(phenyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl(1,2,3,4-tetrahydronaphtalen-2-yl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl-[1-(methylsulfonyl)piperidin-4-yl]amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl-[4-(methylsulfonyl)piperadin-1-yl]amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[[4-(methoxycarbonyl)piperidin-1-yl](methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
-
 Homo sapiens
3.13.2.1 neplanocin
-
 Homo sapiens
3.13.2.1 tert-butyl (2R)-2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
-
 Homo sapiens
3.13.2.1 tert-butyl (2S)-2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
-
 Homo sapiens
3.13.2.1 tert-butyl 2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]piperidine-1-carboxylate
-
 Homo sapiens
3.13.2.1 tert-butyl 3-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]piperidine-1-carboxylate
-
 Homo sapiens
3.13.2.1 tert-butyl 3-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
-
 Homo sapiens
3.13.2.1 tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]ethylcarbamate
-
 Homo sapiens
3.13.2.1 tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]methylcarbamate
-
 Homo sapiens
3.13.2.1 tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]propan-2-ylcarbamate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Homo sapiens
-
 L-homocysteine + adenosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 commercial preparation recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Homo sapiens L-homocysteine + adenosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.13.2.1 AdoHcyase
-
 Homo sapiens
3.13.2.1 S-adenosyl-L-homocysteine hydrolase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.13.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.13.2.1 7.2
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.13.2.1 0.000005
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(methylamino)ethyl]glycinamide hydrochloride
3.13.2.1 0.0000085
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(ethylamino)ethyl]glycinamide hydrochloride
3.13.2.1 0.000013
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.000044
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[[4-(methoxycarbonyl)piperidin-1-yl](methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.000049
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl-[4-(methylsulfonyl)piperadin-1-yl]amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.000049
-
 pH 7.2, 37°C Homo sapiens tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]propan-2-ylcarbamate
3.13.2.1 0.000052
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00006
-
 pH 7.2, 37°C Homo sapiens tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]ethylcarbamate
3.13.2.1 0.00007
-
 pH 7.2, 37°C Homo sapiens tert-butyl [2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]ethyl]methylcarbamate
3.13.2.1 0.000081
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl(1,2,3,4-tetrahydronaphtalen-2-yl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00011
-
 pH 7.2, 37°C Homo sapiens tert-butyl (2S)-2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
3.13.2.1 0.00013
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-[2-(dimethylamino)ethyl]glycinamide
3.13.2.1 0.00015
-
 pH 7.2, 37°C Homo sapiens tert-butyl 2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]piperidine-1-carboxylate
3.13.2.1 0.0002
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroisoquinolin-2(1H)-yl(methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00023
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methyl-[1-(methylsulfonyl)piperidin-4-yl]amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00032
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(2-piperidin-1-ylethyl)glycinamide
3.13.2.1 0.00033
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-(3-pyrrolidin-1-ylpropyl)glycinamide
3.13.2.1 0.00034
-
 pH 7.2, 37°C Homo sapiens 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-methyl-N-(2-phenylethyl)acetamide
3.13.2.1 0.00038
-
 pH 7.2, 37°C Homo sapiens 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-cyclohexyl-N-methylacetamide
3.13.2.1 0.00053
-
 pH 7.2, 37°C Homo sapiens N-benzyl-2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-oxo-2-[[2-(pyrrolidin-1-yl)ethyl]amino]ethyl)amino]-N-methylacetamide
3.13.2.1 0.00053
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[methyl(trans-4-phenylcyclohexyl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.0006
-
 pH 7.2, 37°C Homo sapiens tert-butyl (2R)-2-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
3.13.2.1 0.00064
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[2,3-dihydro-1H-inden-2-yl(ethyl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00089
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00097
-
 pH 7.2, 37°C Homo sapiens 2-[[5-chloro-2-(4-chlorophenoxy)phenyl][2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]amino]-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
3.13.2.1 0.0012
-
 pH 7.2, 37°C Homo sapiens tert-butyl 3-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]piperidine-1-carboxylate
3.13.2.1 0.0015
-
 pH 7.2, 37°C Homo sapiens tert-butyl 3-[2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)(methyl)amino]-2-oxoethyl]amino)acetamido]pyrrolidine-1-carboxylate
3.13.2.1 0.0023
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroquinolin-1(2H)-yl]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.0027
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[methy-(phenyl)amino]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.0046
-
 pH 7.2, 37°C Homo sapiens N2-[2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl]-N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.00878
-
 pH 7.2, 37°C Homo sapiens 2-[[5-chloro-2-(4-chlorophenoxy)phenyl](2-[[(2-fluorophenyl)methyl]amino]-2-oxoethyl)amino]-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
3.13.2.1 0.01136
-
 pH 7.2, 37°C Homo sapiens 2-([5-chloro-2-(4-chlorophenoxy)phenyl][2-[(2,3-dihydro-1H-inden-2-yl)amino]-2-oxoethyl]amino)-N-[2-(pyrrolidin-1-yl)ethyl]acetamide
3.13.2.1 0.017
-
 pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.1
-
 above, pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-(2-[methyl(piperidin-4-yl)amino]-2-oxoethyl)-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.1
-
 above, pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-N1-(2-pyrrolidin-1-ylethyl)glycinamide
3.13.2.1 0.1
-
 above, pH 7.2, 37°C Homo sapiens N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]-N1-methyl(2-pyrrolidin-1-ylethyl)glycinamide