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Literature summary extracted from

  • Grozdanovic, M.M.; Cavic, M.; Nesic, A.; Andjelkovic, U.; Akbari, P.; Smit, J.J.; Gavrovic-Jankulovic, M.
    Kiwifruit cysteine protease actinidin compromises the intestinal barrier by disrupting tight junctions (2016), Biochim. Biophys. Acta, 1860, 516-526 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.14 medicine the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis Actinidia deliciosa

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.14 Actinidia deliciosa A5HII1 Hayward cv
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.14
-
 Actinidia deliciosa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.14 pulp
-
 Actinidia deliciosa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.14 casein + H2O
-
 Actinidia deliciosa ?
-
 ?
3.4.22.14 human occludin + H2O human occludin is fragmented, and putative Act d1 cleavage sites are identified in extracellular loops of human occludin Actinidia deliciosa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.14 Actd1
-
 Actinidia deliciosa

General Information

EC Number General Information Comment Organism
3.4.22.14 additional information the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis Actinidia deliciosa