Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jansen, G.A.; Wanders, R.J.
    L-2-hydroxyglutarate dehydrogenase identification of a novel enzyme activity in rat and human liver. Implications for L-2-hydroxyglutaric acidemia (1993), Biochim. Biophys. Acta, 1225, 53-56 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.99.2 0.2
-
 NAD+ at pH 8.7 and 37°C Homo sapiens
1.1.99.2 0.4
-
 NAD+ at pH 8.7 and 37°C Rattus norvegicus
1.1.99.2 4
-
 L-2-hydroxyglutarate at pH 8.7 and 37°C Homo sapiens
1.1.99.2 13.3
-
 L-2-hydroxyglutarate at pH 8.7 and 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.2 Homo sapiens
-
-
-
1.1.99.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.2 liver
-
 Homo sapiens
-
1.1.99.2 liver
-
 Rattus norvegicus
-
1.1.99.2 additional information no activity in heart, brain and skeletal muscle, cultured human skin fibroblasts and transformed lymphocyte Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.99.2 0.0046
-
 at pH 8.7 and 37°C Rattus norvegicus
1.1.99.2 0.021
-
 at pH 8.7 and 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.2 L-2-hydroxyglutarate + NAD+
-
 Homo sapiens 2-oxoglutarate + NADH + H+
-
 ?
1.1.99.2 L-2-hydroxyglutarate + NAD+
-
 Rattus norvegicus 2-oxoglutarate + NADH + H+
-
 ?
1.1.99.2 additional information no activity with 3-acetylpyridine adenine dinucleotide or NADP+ Homo sapiens ?
-
 ?
1.1.99.2 additional information no activity with 3-acetylpyridine adenine dinucleotide or NADP+ Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.99.2 L-2-hydroxyglutarate dehydrogenase
-
 Homo sapiens
1.1.99.2 L-2-hydroxyglutarate dehydrogenase
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.99.2 7.3 9.3 the enzyme is active over a wide pH range (7.3-9.3) with no clear optimum Homo sapiens
1.1.99.2 7.3 9.3 the enzyme is active over a wide pH range (7.3-9.3) with no clear optimum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.99.2 FAD
-
 Homo sapiens
1.1.99.2 FAD
-
 Rattus norvegicus