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Literature summary extracted from

  • Liu, W.; Shang, F.; Chen, Y.; Lan, J.; Wang, L.; Chen, J.; Gao, P.; Ha, N.C.; Quan, C.; Nam, K.H.; Xu, Y.
    Biochemical and structural analysis of the Klebsiella pneumoniae cytidine deaminase CDA (2019), Biochem. Biophys. Res. Commun., 519, 280-286 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.4.5 to 2.07 A resolution. Two 1,4-dioxane moleules are present at the active site Klebsiella pneumoniae subsp. pneumoniae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.5 Zn2+ involved in the activity of the catalytic domain, coordinated by residues His102, Cys129, and Cys132 Klebsiella pneumoniae subsp. pneumoniae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.5 66000
-
 gel filtration Klebsiella pneumoniae subsp. pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.5 Klebsiella pneumoniae subsp. pneumoniae A6TBN1
-
-
3.5.4.5 Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 A6TBN1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.5 cytarabine + H2O 180% of the activity with cytidine Klebsiella pneumoniae subsp. pneumoniae uridine + NH3
-
 ?
3.5.4.5 cytarabine + H2O 180% of the activity with cytidine Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Klebsiella pneumoniae subsp. pneumoniae uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 uridine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.5 dimer crystallization data, in the dimeric interface, residues Gly94, Ala95, Gln98, Thr100, Gly130, His131, Arg133, Gln134, Pro162, Asp163, Ala200, Asn234, Thr263 and Ile271 participate in hydrogen bonding or salt bridges Klebsiella pneumoniae subsp. pneumoniae