Literature summary extracted from

Sheng, G.H.; Chen, X.F.; Li, J.; Chen, J.; Xu, Y.; Han, Y.W.; Yang, T.; You, Z.; Zhu, H.L.
Synthesis, crystal structures and urease inhibition of N-(2-bromobenzylidene)-2-(4-nitrophenoxy) acetohydrazide and N-(4-nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide (2015), Acta Chim. Slov., 62, 940-946 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.1.5	N'-(2-bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide	-	Helicobacter pylori
3.5.1.5	N'-(4-nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide	-	Helicobacter pylori

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.5	Helicobacter pylori	-	-	-
3.5.1.5	Helicobacter pylori ATCC 43504	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.1.5	urea + H2O	-	Helicobacter pylori	CO2 + 2 NH3	-	?
3.5.1.5	urea + H2O	-	Helicobacter pylori ATCC 43504	CO2 + 2 NH3	-	?

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.5.1.5	0.0084	-	23°C, pH not specified in the publication	Helicobacter pylori	N'-(2-bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide
3.5.1.5	0.0202	-	23°C, pH not specified in the publication	Helicobacter pylori	N'-(4-nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide

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Release 2023.1 (January 2023)