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Literature summary extracted from

  • Starai, V.J.; Celic, I.; Cole, R.N.; Boeke, J.D.; Escalante-Semerena, J.C.
    Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine (2002), Science, 298, 2390-2392 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O Salmonella enterica the enzyme activates Acs protein by deacetylation [Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O the enzyme activates Acs protein by deacetylation Salmonella enterica [Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 CobB
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 Salmonella enterica
2.3.1.286 nicotinamide adenine dinucleotide-dependent protein deacetylase
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 Salmonella enterica
2.3.1.286 Sir2
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 Salmonella enterica

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Salmonella enterica