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Literature summary extracted from

  • Fischer, F.; Robbe-Saule, M.; Turlin, E.; Mancuso, F.; Michel, V.; Richaud, P.; Veyrier, F.; De Reuse, H.; Vinella, D.
    Characterization in Helicobacter pylori of a nickel transporter essential for colonization that was acquired during evolution by gastric Helicobacter species (2016), PLoS Pathog., 12, e1006018 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.11 periplasm
-
 Helicobacter pylori
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.11 ATP + H2O + Bi3+-[bismuth-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Bi3+-[bismuth-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Co2+-[cobalt-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Co2+-[cobalt-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Ni2+-[nickel-binding protein][side 1] Helicobacter pylori
-
 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Ni2+-[nickel-binding protein][side 1] Helicobacter pylori G27
-
 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.11 Helicobacter pylori
-
-
-
7.2.2.11 Helicobacter pylori G27
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.11 ATP + H2O + Bi3+-[bismuth-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Bi3+-[bismuth-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Bi3+[side 2] + [bismuth-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Co2+-[cobalt-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Co2+-[cobalt-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Co2+[side 2] + [cobalt-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Ni2+-[nickel-binding protein][side 1]
-
 Helicobacter pylori ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?
7.2.2.11 ATP + H2O + Ni2+-[nickel-binding protein][side 1]
-
 Helicobacter pylori G27 ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.11 nickel transporter
-
 Helicobacter pylori
7.2.2.11 NiuBDE
-
 Helicobacter pylori

General Information

EC Number General Information Comment Organism
7.2.2.11 physiological function the enzyme is indispensable for colonization of the mouse model by Helicobacter pylori. The enzyme participates in nickel-dependent urease activation at pH 5.0 and survival under acidic conditions mimicking those encountered in the stomach. The enzyme is also able to carry out this activity at neutral pH and is essential for colonization of the mouse stomach Helicobacter pylori