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Literature summary extracted from

  • Clarke, F.; Jordan, C.K.; Gutierrez-Martinez, E.; Bibby, J.A.; Sanchez-Blanco, C.; Cornish, G.H.; Dai, X.; Rawlings, D.J.; Zamoyska, R.; Guermonprez, P.; Cope, A.P.; Purvis, H.A.
    Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells (2017), PLoS ONE, 12, e0186625 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.48 gene Ptpn22, real-time PCR expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 R619W naturally occuring polymorphisms, phenotype, overview. Ptpn22-/- mice and Ptpn22R619W mutant mice are backcrossed for more than 10 generations to the C57BL/6 strain, genotyping and phenotyping in bone marrow derived dendritic cell culture, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Mus musculus
-
 [a protein]-tyrosine + phosphate
-
 ?
3.1.3.48 [a protein]-tyrosine phosphate + H2O Mus musculus C57BL/6
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mus musculus E9QAS3
-
-
3.1.3.48 Mus musculus C57BL/6 E9QAS3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 bone marrow-derived dendritic cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Mus musculus [a protein]-tyrosine + phosphate
-
 ?
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Mus musculus C57BL/6 [a protein]-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase
-
 Mus musculus
3.1.3.48 PTPN22
-
 Mus musculus
3.1.3.48 tyrosine-protein phosphatase non-receptor type 22 UniProt Mus musculus

General Information

EC Number General Information Comment Organism
3.1.3.48 malfunction the C1858T polymorphism within the protein tyrosine phosphatase PTPN22 (encoding PTPN22R619W) is a major risk factor for the development of multiple autoimmune diseases, including rheumatoid arthritis (RA), type I diabetes, lupus and juvenile idiopathic arthritis (JIA). The autoimmune associated PTPN22R619W variant displays reduced binding to the tyrosine kinase Csk, due to a missense mutation in the P1 domain. Ptpn22 variants do not alter BMDC receptor mediated phagocytosis Mus musculus
3.1.3.48 physiological function Ptpn22 in the mouse negatively regulates Src and Syk family kinase (SFK) activity downstream of the T-cell antigen receptor (TCR). In addition to TCR signalling, PTPN22 regulates many pathways in different cell types including the B-cell receptor, the alphaLbeta2 integrin LFA-1 and Toll-Like Receptor (TLR) signalling pathways. Ptpn22 also functions to alter SFK independent signalling events by modulating TRAF ubiquitination. Macropinocytosis does not require Ptpn22. Splenic dendritic cell uptake of ovalbumin occurs independently of Ptpn22. Ptpn22 is dispensable for antigen processing and presentation and is redundant for dendritic cell activation of antigen specific T-cells. Ptpn22 variants do not modulate BMDC dependent OT-II T-cell activation Mus musculus