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Literature summary extracted from

  • Correa, M.A.; Okamoto, C.K.; Goncalves-de-Andrade, R.M.; van den Berg, C.W.; Tambourgi, D.V.
    Sphingomyelinase D from Loxosceles laeta venom induces the expression of MMP7 in human keratinocytes contribution to dermonecrosis (2016), PLoS ONE, 11, e0153090 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 sphingomyelin + H2O Loxosceles laeta
-
 ceramide phosphate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Loxosceles laeta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.41 venom
-
 Loxosceles laeta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 sphingomyelin + H2O
-
 Loxosceles laeta ceramide phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.41 SMase D
-
 Loxosceles laeta

General Information

EC Number General Information Comment Organism
3.1.4.41 physiological function in loxoscelism, the enzyme increases the expression/secretion of matrix metalloproteinases MMP2 and MMP9 and also stimulates the expression of MMP7 (matrilysin-1), which is associated with keratinocyte cell death Loxosceles laeta