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Literature summary extracted from

  • Ellis, J.M.; Bowman, C.E.; Wolfgang, M.J.
    Metabolic and tissue-specific regulation of acyl-CoA metabolism (2015), PLoS ONE, 10, e0116587 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.20 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.20 acyl-CoA + H2O Mus musculus
-
 CoA + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.20 Mus musculus Q8VHQ9
-
-
3.1.2.20 Mus musculus Q91V12
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.20 brain
-
 Mus musculus
-
3.1.2.20 brown adipose tissue
-
 Mus musculus
-
3.1.2.20 duodenum
-
 Mus musculus
-
3.1.2.20 gonad
-
 Mus musculus
-
3.1.2.20 heart
-
 Mus musculus
-
3.1.2.20 kidney
-
 Mus musculus
-
3.1.2.20 liver
-
 Mus musculus
-
3.1.2.20 neuron
-
 Mus musculus
-
3.1.2.20 plantaris muscle
-
 Mus musculus
-
3.1.2.20 soleus
-
 Mus musculus
-
3.1.2.20 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.20 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.20 ACOT
-
 Mus musculus
3.1.2.20 Acot11 isoform Mus musculus
3.1.2.20 Acot7 isoform Mus musculus
3.1.2.20 acyl-CoA thioesterase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.2.20 Mus musculus isoform Acot11 is up-regulated in adipose and liver during conditions that increase lipid anabolic processes, specifically Acot11 is up-regulated 10 and 34fold in FR (control diet fed mice fasted for 14 hours then refed for 12 hours overnight) gonadal white adipose tissue and inguinal white adipose tissue, respectively, and 5fold and 13fold in liver during FR and high-fat diet, respectively up

General Information

EC Number General Information Comment Organism
3.1.2.20 physiological function doubling cytosolic enzyme activity fails to protect mice from diet-induced obesity, fatty liver or insulin resistance, however, overexpression of isoform Acot7 in adipocytes renders mice cold intolerant Mus musculus