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Literature summary extracted from

  • Dempke, W.C.M.; Uciechowski, P.; Fenchel, K.; Chevassut, T.
    Targeting SHP-1, 2 and SHIP pathways a novel strategy for cancer treatment? (2018), Oncology, 95, 257-269 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.86 3-alpha-aminocholestane selective inhibitor of isoform SHIP-1 Homo sapiens
3.1.3.86 AQX-1125 Rosiptor, inhibitor of isoform SHIP-1 Homo sapiens
3.1.3.86 NSC13480
-
 Homo sapiens
3.1.3.86 NSC305787
-
 Homo sapiens
3.1.3.86 sodium stibogluconate inhibitor of isoform SHIP-1 Homo sapiens
3.1.3.86 TNO155 inhibitor of isoform SHIP-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.86 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.86 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.86 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.86 Homo sapiens O15357
-
-
3.1.3.86 Homo sapiens Q92835
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.86 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.86 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.86 ? x * 142000, isoform SHIP-2, SDS-PAGE Homo sapiens
3.1.3.86 ? x * 145000, isoform SHIP-1, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.86 INPP5D
-
 Homo sapiens
3.1.3.86 INPPL1
-
 Homo sapiens
3.1.3.86 SHIP-1 isoform Homo sapiens
3.1.3.86 SHIP-2 isoform Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.86 malfunction enzyme deficiency leads to myeloproliferation and B-cell lymphoma in mice Homo sapiens
3.1.3.86 physiological function the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-1 is also implicated both as a haematopoietic tumour suppressor and activator Homo sapiens
3.1.3.86 physiological function the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-2 is a negative regulator of glucose homeostasis and is involved in the maturation and activation of mast cells as well as in phagocytosis directed by Fc receptors for immunoglobulin G, thus regulating allergic reactions and antibacterial defense Homo sapiens