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Literature summary extracted from

  • Manohar, M.; Choi, H.W.; Manosalva, P.; Austin, C.A.; Peters, J.E.; Klessig, D.F.
    Plant and human MORC proteins have DNA-modifying activities similar to type II topoisomerases, but require one or more additional factors for full activity (2017), Mol. Plant Microbe Interact., 30, 87-100 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 etoposide the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Homo sapiens
5.6.2.2 etoposide the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Solanum lycopersicum
5.6.2.2 geldanamycin geldanamycin suppresses the ATPase activity of the enzyme Homo sapiens
5.6.2.2 geldanamycin geldanamycin suppresses the ATPase activity of the enzyme Solanum lycopersicum
5.6.2.2 radicicol radicicol suppresses the ATPase activity of the enzyme Homo sapiens
5.6.2.2 radicicol radicicol suppresses the ATPase activity of the enzyme Solanum lycopersicum
5.6.2.2 razoxane the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Homo sapiens
5.6.2.2 razoxane the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Solanum lycopersicum
5.6.2.2 salicylic acid salicylic acid suppresses the ATPase and decatenation but not relaxation activity of the enzyme Homo sapiens
5.6.2.2 salicylic acid salicylic acid suppresses the ATPase and decatenation but not relaxation activity of the enzyme Solanum lycopersicum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 Mg2+ required for ATPase activity Homo sapiens
5.6.2.2 Mg2+ required for ATPase activity Solanum lycopersicum
5.6.2.2 Mn2+ required for ATPase activity Homo sapiens
5.6.2.2 Mn2+ required for ATPase activity Solanum lycopersicum
5.6.2.2 additional information not influenced by K+, Na+, or Ni2+ Homo sapiens
5.6.2.2 additional information not influenced by K+, Na+, or Ni2+ Solanum lycopersicum

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-
5.6.2.2 Solanum lycopersicum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 ATP + catenated kinetoplast DNA
-
 Homo sapiens ADP + phosphate + decatenated kinetoplast DNA
-
 ?
5.6.2.2 ATP + catenated kinetoplast DNA
-
 Solanum lycopersicum ADP + phosphate + decatenated kinetoplast DNA
-
 ?
5.6.2.2 ATP + decatenated DNA
-
 Homo sapiens ADP + phosphate + catenated DNA
-
 ?
5.6.2.2 ATP + decatenated DNA
-
 Solanum lycopersicum ADP + phosphate + catenated DNA
-
 ?
5.6.2.2 ATP + negatively supercoiled pER8:hemagglutinin plasmid DNA
-
 Homo sapiens ADP + phosphate + relaxed pER8:hemagglutinin plasmid DNA
-
 ?
5.6.2.2 ATP + negatively supercoiled pER8:hemagglutinin plasmid DNA
-
 Solanum lycopersicum ADP + phosphate + relaxed pER8:hemagglutinin plasmid DNA
-
 ?
5.6.2.2 ATP + supercoiled pUC19 DNA
-
 Homo sapiens ADP + phosphate + nicked pUC19 DNA
-
 ?
5.6.2.2 ATP + supercoiled pUC19 DNA
-
 Solanum lycopersicum ADP + phosphate + nicked pUC19 DNA
-
 ?
5.6.2.2 ATP + supercoiled pUC19 DNA
-
 Homo sapiens ADP + phosphate + relaxed pUC19 DNA
-
 ?
5.6.2.2 ATP + supercoiled pUC19 DNA
-
 Solanum lycopersicum ADP + phosphate + relaxed pUC19 DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA topoisomerase II
-
 Homo sapiens
5.6.2.2 DNA topoisomerase II
-
 Solanum lycopersicum
5.6.2.2 microrchidia protein
-
 Homo sapiens
5.6.2.2 microrchidia protein
-
 Solanum lycopersicum
5.6.2.2 MORC1
-
 Homo sapiens
5.6.2.2 MORC1
-
 Solanum lycopersicum
5.6.2.2 topo II
-
 Homo sapiens
5.6.2.2 topo II
-
 Solanum lycopersicum