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Literature summary extracted from

  • Blosser, S.; Merriman, B.; Grahl, N.; Chung, D.; Cramer, R.
    Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus (2014), Microbiology, 160, 2492-2506 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.10 Iron non-heme iron-requiring enzyme Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.10 Aspergillus fumigatus
-
-
-
1.14.18.10 Aspergillus fumigatus CEA17
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.10 4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol Aspergillus fumigatus 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O
-
 ?
1.14.18.10 4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol Aspergillus fumigatus CEA17 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O
-
 ?
1.14.18.10 parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol Aspergillus fumigatus 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O
-
 ?
1.14.18.10 parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol Aspergillus fumigatus CEA17 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.10 C4-sterol methyl oxidase
-
 Aspergillus fumigatus
1.14.18.10 Erg25A isoform Aspergillus fumigatus
1.14.18.10 Erg25B isoform Aspergillus fumigatus
1.14.18.10 SMO
-
 Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
1.14.18.10 malfunction a erg25A deletion strain displays moderate susceptibility to hypoxia and the endoplasmic reticulum stress-inducing agent dithiothreitol, but is not required for virulence in murine or insect models of invasive aspergillosis Aspergillus fumigatus
1.14.18.10 physiological function isoform Erg25A is not required for virulence of Aspergillus fumigatus Aspergillus fumigatus