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Literature summary extracted from

  • Du, W.; Dai, M.; Li, Z.; Boons, G.J.; Peeters, B.; van Kuppeveld, F.J.M.; de Vries, E.; de Haan, C.A.M.
    Substrate binding by the second sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity (2018), J. Virol., 92, e01243-18.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.18 A284T the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 H155Y the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 I400M the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 K432E the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 M257I the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 N369H the mutation increases enzymatic activity influenza A virus H5N1
3.2.1.18 S372H the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 S372N the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 S389R the mutation decreases enzymatic activity for transferrin and increases enzymatic activity for fetuin influenza A virus H5N1
3.2.1.18 S434D the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 V99I the mutation increases enzymatic activity influenza A virus H5N1
3.2.1.18 W403R the mutation decreases enzymatic activity influenza A virus H5N1
3.2.1.18 Y347N the mutation increases enzymatic activity influenza A virus H5N1

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 influenza A virus H1N1 M1VAT9 A/duck/Hunan/795/2002
-
3.2.1.18 influenza A virus H5N1 Q6DPL4 A/Vietnam/1194/2004
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
-
 influenza A virus H1N1 4-methylumbelliferone + alpha-D-N-acetylneuraminic acid
-
 ?
3.2.1.18 4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
-
 influenza A virus H5N1 4-methylumbelliferone + alpha-D-N-acetylneuraminic acid
-
 ?
3.2.1.18 fetuin + H2O
-
 influenza A virus H1N1 ?
-
 ?
3.2.1.18 fetuin + H2O
-
 influenza A virus H5N1 ?
-
 ?
3.2.1.18 additional information the enzyme prefers cleaving alpha2,3- over alpha2,6-linked sialic acids influenza A virus H1N1 ?
-
 ?
3.2.1.18 additional information the enzyme prefers cleaving alpha2,3- over alpha2,6-linked sialic acids influenza A virus H5N1 ?
-
 ?
3.2.1.18 transferrin + H2O
-
 influenza A virus H1N1 ?
-
 ?
3.2.1.18 transferrin + H2O
-
 influenza A virus H5N1 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 neuraminidase
-
 influenza A virus H1N1
3.2.1.18 neuraminidase
-
 influenza A virus H5N1