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Literature summary extracted from
- A closely associated phospholipase C regulates cation channel function through phosphoinositide hydrolysis (2018), J. Neurosci., 38, 7622-7634 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.11 | N-(3-trifluoromethyl-phenyl)-2,4,6-trimethylbenzenesulfonamide | - |
Aplysia californica |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.11 | U-73122 | - |
Aplysia californica | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.11 | plasma membrane | the enzyme associates with the cation channel in excised patches | Aplysia californica | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Aplysia californica | - |
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.11 | Aplysia californica | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.11 | bag cell neuron | - |
Aplysia californica | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.11 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Aplysia californica | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.11 | phospholipase C | - |
Aplysia californica |
| 3.1.4.11 | PLC | - |
Aplysia californica |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.4.11 | physiological function | enzyme-mediated lipid signaling controls single-channel currents to ensure depolarization is maintained for an extended period of firing, termed the after discharge, when the bag cell neurons secrete egg-laying hormone to trigger reproduction. Enzyme-mediated 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown products modulate cation channel activity and left-shift cation channel voltage dependence | Aplysia californica |
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Release 2023.1 (January 2023)
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