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Literature summary extracted from

  • Kang, W.K.; Devare, M.; Kim, J.Y.
    HST1 increases replicative lifespan of a sir2DELTA mutant in the absence of PDE2 in Saccharomyces cerevisiae (2017), J. Microbiol., 55, 123-129 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae BY4741
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Saccharomyces cerevisiae
-
-
-
2.3.1.286 Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O overall reaction Saccharomyces cerevisiae [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O overall reaction Saccharomyces cerevisiae BY4741 [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae BY4741 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 Hst1
-
 Saccharomyces cerevisiae
2.3.1.286 silent information regulator 2
-
 Saccharomyces cerevisiae
2.3.1.286 Sir2
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.1.286 physiological function the enzyme is a pro-longevity factor for replicative lifespan in Saccharomyces cerevisiae. The enzyme is required for transcriptional silencing at mating type loci, telomeres, and rDNA loci. The enzyme also represses transcription of highly expressed growth-related genes, such as PMA1 and some ribosomal protein genes Saccharomyces cerevisiae