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Literature summary extracted from

  • Ferre, D.M.; Lentini, V.R.; Romano, R.R.; Luduena, H.R.; Jotallan, P.J.; Gorla, N.B.M.
    Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos (2018), J. Environ. Sci. Health B, 53, 191-198 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 acetylthiocholine the enzyme AChE is inhibited by high concentrations of substrate Bos taurus
3.1.1.7 chlorpyrifos an anti-cholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos, applied by pour-on according to the manufacturer's instructions, does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine Bos taurus
3.1.1.8 chlorpyrifos an anticholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine Bos taurus
3.1.1.8 additional information enzyme BChE is not inhibited by high concentrations of substrate Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O Bos taurus
-
 thiocholine + acetate
-
 ?
3.1.1.8 acetylthiocholine + H2O Bos taurus
-
 thiocholine + acetate
-
 ?
3.1.1.8 butyrylcholine + H2O Bos taurus
-
 choline + butyrate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Bos taurus P23795 Aberdeen Angus beef cattle and crossbred steers, meat steers
-
3.1.1.8 Bos taurus P32749 Aberdeen Angus beef cattle and crossbred steers, meat steers
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 erythrocyte
-
 Bos taurus
-
3.1.1.8 blood plasma
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Bos taurus thiocholine + acetate
-
 ?
3.1.1.8 acetylthiocholine + H2O
-
 Bos taurus thiocholine + acetate
-
 ?
3.1.1.8 butyrylcholine + H2O
-
 Bos taurus choline + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 acetylcholinesterase
-
 Bos taurus
3.1.1.7 AChE
-
 Bos taurus
3.1.1.8 BChE
-
 Bos taurus
3.1.1.8 butyrylcholinesterase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 30
-
 assay at Bos taurus
3.1.1.8 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.4
-
 assay at Bos taurus
3.1.1.8 7.4
-
 assay at Bos taurus

General Information

EC Number General Information Comment Organism
3.1.1.7 physiological function acetylcholinesterase (AChE) is mainly present in erythrocytes, typically hydrolyzes acetylthiocholine (ATC) and is inhibited by excessive substrate. In cattle, 90% of cholinesterase enzyme activity is represented by AChE in erythrocytes with very low plasma BChE values Bos taurus
3.1.1.8 physiological function butyrylcholinesterase (BChE) is mainly present in plasma and generally hydrolyzes butyrylthiocholine at a higher rate than acetylthiocholine but unlike acetylcholinesterase (AChE, EC 3.1.1.7), it is not inhibited by high concentrations of substrate. In cattle, 90% of cholinesterase enzyme activity is represented by AChE in erythrocytes with very low plasma BChE values Bos taurus