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Literature summary extracted from
- A high-throughput enzyme-coupled assay for SAMHD1 dNTPase (2015), J. Biomol. Screen., 20, 801-809 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.5.B1 | analysis | high-throughput colorimetric assay for dNTP hydrolase activity, using Escherichia coli inorganic pyrophosphatase to convert triphosphate to 3 phosphates | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.5.B1 | expression in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.5.B1 | acycloguanosine | - |
Homo sapiens |  |
| 3.1.5.B1 | cephalosporin C | zinc salt, inhibition is largely attributable to zinc | Homo sapiens | |
| 3.1.5.B1 | Zn2+ | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.5.B1 | Homo sapiens | Q9Y3Z3 | - |
- |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.5.B1 | 0.0011 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | cephalosporin C | |
| 3.1.5.B1 | 0.0021 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | Zn2+ | |
| 3.1.5.B1 | 0.764 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | acycloguanosine | |
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Release 2023.1 (January 2023)
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