Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jang, K.K.; Lee, Z.W.; Kim, B.; Jung, Y.H.; Han, H.J.; Kim, M.H.; Kim, B.S.; Choi, S.H.
    Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis (2017), J. Biol. Chem., 292, 17129-17143 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.4 up plpA transcription is growth phase-dependent, reaching maximum levels during the early stationary phase. Transcription factor HlyU and cAMP receptor protein mediate additive activation and host-dependent induction of plpA Vibrio vulnificus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Vibrio vulnificus
-
-
-
3.1.1.4 Vibrio vulnificus MO6-24/O
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
-
 Vibrio vulnificus 1-oleoyl-sn-glycero-3-phosphocholine + oleic acid
-
 ?
3.1.1.4 1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
-
 Vibrio vulnificus MO6-24/O 1-oleoyl-sn-glycero-3-phosphocholine + oleic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 plpA gtene name Vibrio vulnificus

General Information

EC Number General Information Comment Organism
3.1.1.4 malfunction compared with the wild type, the plpA mutant exhibis reduced mortality, systemic infection, and inflammation in mice as well as low cytotoxicity toward the human epithelial INT-407 cells Vibrio vulnificus
3.1.1.4 physiological function the enzyme is essential for pathogenesis Vibrio vulnificus