Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
    New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus (2016), J. Biol. Chem., 291, 26970-26986 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.7 guanosine pentaphosphate
-
 Staphylococcus aureus
3.1.4.59 guanosine pentaphosphate
-
 Staphylococcus aureus
3.1.4.60 ppGpp
-
 Staphylococcus aureus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.7 cytoplasm
-
 Staphylococcus aureus 5737
-
3.1.4.59 cytoplasm
-
 Staphylococcus aureus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.60 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O Staphylococcus aureus
-
 2 AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.7 Staphylococcus aureus A0A0H2XFX6
-
-
3.1.3.7 Staphylococcus aureus USA300 A0A0H2XFX6
-
-
3.1.4.59 Staphylococcus aureus A0A0H2XFX6
-
-
3.1.4.59 Staphylococcus aureus USA300 A0A0H2XFX6
-
-
3.1.4.60 Staphylococcus aureus A0A0H2XFX6 USA300
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.7 adenosine 3',5'-bisphosphate + H2O
-
 Staphylococcus aureus AMP + phosphate
-
 ?
3.1.3.7 adenosine 3',5'-bisphosphate + H2O
-
 Staphylococcus aureus USA300 AMP + phosphate
-
 ?
3.1.3.7 additional information isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP Staphylococcus aureus ?
-
 ?
3.1.3.7 additional information isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP Staphylococcus aureus USA300 ?
-
 ?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Staphylococcus aureus 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Staphylococcus aureus USA300 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
3.1.4.59 additional information isoform Pde2 is capable of hydrolyzing c-di-AMP and Pde2 preferentially converts linear 5'-phosphonoadenylyl-adenosine (pApA) to AMP, reaction of EC 3.1.3.7. No substrate: ATP Staphylococcus aureus ?
-
 ?
3.1.4.59 additional information isoform Pde2 is capable of hydrolyzing c-di-AMP and Pde2 preferentially converts linear 5'-phosphonoadenylyl-adenosine (pApA) to AMP, reaction of EC 3.1.3.7. No substrate: ATP Staphylococcus aureus USA300 ?
-
 ?
3.1.4.60 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
 Staphylococcus aureus 2 AMP
-
 ?
3.1.4.60 additional information Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP Staphylococcus aureus ?
-
 ?
3.1.4.60 additional information Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP Staphylococcus aureus USA300 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.7 PDE2
-
 Staphylococcus aureus
3.1.4.59 PDE2
-
 Staphylococcus aureus
3.1.4.60 SAUSA300_1650
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.1.3.7 physiological function a Pde2 mutant strain displays a growth defect in the early growth phase. Mutation leads to an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased resistance to oxacillin Staphylococcus aureus
3.1.4.59 physiological function a Pde2 mutant strain displays a growth defect in the early growth phase. Mutation leads to an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased resistance to oxacillin Staphylococcus aureus
3.1.4.60 physiological function a Pde2 mutant strain displays a growth defect in the early growth phase. The mutant displays an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased oxacillin resistance. A strain producing a high level of c-di-AMP has increased and a stain producing low levels has decreased acid resistance Staphylococcus aureus