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Literature summary extracted from

  • Zwick, M.; Esposito, C.; Hellstern, M.; Seelig, A.
    How phosphorylation and ATPase activity regulate anion flux though the cystic fibrosis transmembrane conductance regulator (CFTR) (2016), J. Biol. Chem., 291, 14483-14498 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.6 8-(4-chlorophenylthio)-AMP the ATPase activity of the enzyme is enhanced in the presence of very low concentrations of 8-(4-chlorophenylthio)-AMP Homo sapiens
5.6.1.6 additional information the ATPase activity of the enzyme is enhanced by anion channel inhibitors including glibenclamide, glipizide, and CFTRinh-172 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.6 expressed in Chinese hamster ovary and baby hamster kidney cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 E1371S the mutant has no ATPase activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 8-(4-chlorophenylthio)-AMP the ATPase activity of the enzyme is reduced in the presence of higher concentrations of 8-(4-chlorophenylthio)-AMP Homo sapiens
5.6.1.6 CFTRinh-172 i.e., 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]4-thiazolidinone Homo sapiens
5.6.1.6 glibenclamide
-
 Homo sapiens
5.6.1.6 glipizide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed I- channel Homo sapiens
-
 ADP + phosphate + open I- channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
5.6.1.6 phosphoprotein phosphorylation by protein kinase A occurs in the post-hydrolysis transition state of the enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed I- channel
-
 Homo sapiens ADP + phosphate + open I- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 ABCC7
-
 Homo sapiens
5.6.1.6 CFTR
-
 Homo sapiens
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.6.1.6 14
-
 ATP partially phosphorylated enzyme, at pH 7.4 and 37°C Homo sapiens