EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.286 | expressed in Escherichia coli BL21(DE3) cells | Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.286 | acetyl-protamine | - |
Saccharomyces cerevisiae | |
2.3.1.286 | poly-L-arginine | - |
Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.286 | [protein]-N6-acetyl-L-lysine + NAD+ + H2O | Saccharomyces cerevisiae | - |
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.286 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.286 | acetyl-cytochrome c + NAD+ + H2O | the enzyme does not deacetylate native acetyl-cytochrome c but does deacetylate the heat-denatured substrate | Saccharomyces cerevisiae | ? | - |
? | |
2.3.1.286 | acetyl-poly-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
2.3.1.286 | additional information | the enzyme is specific for acetyl-lysine within proteins. It does not deacetylate small polycations such as acetyl-spermine or acetyl-protamine or acetylated amino termini of proteins. Furthermore, the enzyme displays conformational rather than sequence specificity, preferentially deacetylating acetyl-lysine within unstructured regions of proteins | Saccharomyces cerevisiae | ? | - |
? | |
2.3.1.286 | [histone H2B]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [histone H2B]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
2.3.1.286 | [histone H2]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [histone H2]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
2.3.1.286 | [histone H3]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
2.3.1.286 | [histone H4]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
2.3.1.286 | [protein]-N6-acetyl-L-lysine + NAD+ + H2O | - |
Saccharomyces cerevisiae | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.286 | HST2 | - |
Saccharomyces cerevisiae |
2.3.1.286 | Sir2 | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.286 | NAD+ | - |
Saccharomyces cerevisiae |