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Literature summary extracted from
- Chlorpromazine and dimethyl sulfoxide modulate the catalytic activity of the plasma membrane Ca2+-ATPase from human erythrocyte (2018), J. Bioenerg. Biomembr., 50, 59-69 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | Calmodulin | 177% activity in the presence of 0.002 mg/ml calmodulin | Homo sapiens |  |
| 7.2.2.10 | Trypsin | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | chlorpromazine | non-competitive inhibition, complete inhibition at 1 mM | Homo sapiens | |
| 7.2.2.10 | dimethyl sulfoxide | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.10 | plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | Homo sapiens | - |
ADP + phosphate + Ca2+[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | - |
Homo sapiens | ADP + phosphate + Ca2+[side 2] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | plasma membrane Ca2+-ATPase | - |
Homo sapiens |
| 7.2.2.10 | PMCA | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.2.2.10 | 0.085 | - |
trypsin-activated enzyme, at pH 7.2 and 25°C | Homo sapiens | chlorpromazine | |
| 7.2.2.10 | 0.15 | - |
native enzyme in the presence of 0.002 mg/ml calmodulin, at pH 7.2 and 25°C | Homo sapiens | chlorpromazine | |
| 7.2.2.10 | 0.42 | - |
native enzyme, at pH 7.2 and 25°C | Homo sapiens | chlorpromazine | |
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Release 2023.1 (January 2023)
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