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Literature summary extracted from

  • Minami, A.; Ishii, A.; Shimba, S.; Kano, T.; Fujioka, E.; Sai, S.; Oshio, N.; Ishibashi, S.; Takahashi, T.; Kurebayashi, Y.; Kanazawa, H.; Yuki, N.; Otsubo, T.; Ikeda, K.; Suzuki, T.
    Down-regulation of glutamate release from hippocampal neurons by sialidase (2018), J. Biochem., 163, 273-280 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 2,3-dehydro-2-deoxy-N-glycolylneuraminic acid
-
 Rattus norvegicus
3.2.1.18 2-deoxy-2,3-didehydro-D-N-acetylneuraminic acid
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.18 ganglioside GQ1b + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.18 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 ganglioside GQ1b + H2O
-
 Rattus norvegicus ?
-
 ?

Expression

EC Number Organism Comment Expression
3.2.1.18 Rattus norvegicus enzyme activity is rapidly increased in response to neural excitation up

General Information

EC Number General Information Comment Organism
3.2.1.18 physiological function the enzyme is essential for hippocampal memory and synaptic plasticity. The enzyme down-regulates glutamate release from hippocampal neurons via Ca2+ signalling modulation Rattus norvegicus