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Literature summary extracted from
- Copper ATPase CopA from Escherichia coli quantitative correlation between ATPase activity and vectorial copper transport (2017), J. Am. Chem. Soc., 139, 4266-4269 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.2.2.8 | expression in Escherichia coli | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.8 | vanadate | 0.2 mM, complete inhibition. Vanadate binds irreversibly to the P-domain phosphorylation site | Escherichia coli |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.8 | membrane | inner membrane | Escherichia coli | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.8 | copper | enzyme binds Cu(I) witrh subfemtomolar affinity | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.8 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.8 | ATP + H2O + Cu+[side 1] | - |
Escherichia coli | ADP + phosphate + Cu+[side 2] | - |
? | |
| 7.2.2.8 | additional information | in giant unilamellar vesicles, no Cu leakage or passive diffusion is found. The observed Cu uptake relies completely on active transportation | Escherichia coli | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | ? | x * 87900, SDS-PAGE | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | CopA | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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