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Literature summary extracted from

  • Yu, J.; Wang, X.; Lu, Q.; Wang, J.; Li, L.; Liao, X.; Zhu, W.; Lv, L.; Zhi, X.; Yu, J.; Jin, Y.; Zou, Q.; Ou, Z.; Liu, X.; Zhou, P.
    Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3beta/beta-catenin/cyclinD1 signaling pathway (2018), Int. J. Cancer, 142, 959-967 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 alpha,beta-methylene-ADP specific inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.5 extracellular
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens P21589
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 breast cancer cell
-
 Homo sapiens
-
3.1.3.5 BT-549 cell
-
 Homo sapiens
-
3.1.3.5 MCF-10A cell
-
 Homo sapiens
-
3.1.3.5 MCF-7 cell
-
 Homo sapiens
-
3.1.3.5 MDA-MB-231 cell
-
 Homo sapiens
-
3.1.3.5 T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 5'-nucleotidase
-
 Homo sapiens
3.1.3.5 CD73
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.3.5 Homo sapiens the expression of the enzyme is high in breast cancer tissues and increases with advanced tumor grades and lympho-node status up

General Information

EC Number General Information Comment Organism
3.1.3.5 physiological function enzyme overexpression promotes breast cancer cell proliferation by stimulating the AKT/GSK-3beta/beta-catenin signal pathway Homo sapiens