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Literature summary extracted from

  • Sauve, A.A.; Schramm, V.L.
    SIR2 the biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates (2004), Curr. Med. Chem., 11, 807-826 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.286 nicotinamide
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ Saccharomyces cerevisiae
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 AGG(AcK)GG(AcK)GMG(AcK)VGA(AcK)RHSC + NAD+ + H2O tetraacetylated histone-H4 N-terminal tail peptide Saccharomyces cerevisiae AGG(AcK)GG(AcK)GMG(AcK)VGAKRHSC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 ARTKQTAR(AcK)STGG(AcK)APRKQLC + NAD+ + H2O diacetyl ated histone-H3 N-terminal tail peptide Saccharomyces cerevisiae ARTKQTARKSTGGKAPRKQLC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+
-
 Saccharomyces cerevisiae [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 Sir2
-
 Saccharomyces cerevisiae
2.3.1.286 Sir2p
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.1.286 physiological function increase of enzyme activity by caloric restriction or osmotic stress increases genome stability and lifespan in Saccharomyces cerevisiae Saccharomyces cerevisiae