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Literature summary extracted from

  • Keijzers, G.; Liu, D.; Rasmussen, L.
    Exonuclease 1 and its versatile roles in DNA repair (2016), Crit. Rev. Biochem. Mol. Biol., 51, 440-451 .
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.11.1 14-3-3 isoform eta
-
 Homo sapiens
3.1.11.1 14-3-3 isoform sigma
-
 Homo sapiens
3.1.11.1 proliferating cell nuclear antigen
-
 Homo sapiens

General Stability

EC Number General Stability Organism
3.1.11.1 ultraviolet C radiation, ionizing radiation, cisplatin and methylnitronitrosoguanidine do not affect the stability of the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.11.1 nicked DNA containing mismatches + H2O Homo sapiens
-
 ?
-
 ?
3.1.11.1 single-stranded oligodeoxyribonucleotide + H2O Homo sapiens
-
 single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
 ?
3.1.11.1 ssDNA + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.11.1 Homo sapiens Q9UQ84
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.11.1 phosphoprotein
-
 Homo sapiens
3.1.11.1 ubiquitination
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.11.1 colon
-
 Homo sapiens
-
3.1.11.1 placenta
-
 Homo sapiens
-
3.1.11.1 testis
-
 Homo sapiens
-
3.1.11.1 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.11.1 nicked DNA containing mismatches + H2O
-
 Homo sapiens ?
-
 ?
3.1.11.1 single-stranded oligodeoxyribonucleotide + H2O
-
 Homo sapiens single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
 ?
3.1.11.1 ssDNA + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.11.1 Exo1
-
 Homo sapiens
3.1.11.1 exonuclease 1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.11.1 malfunction enzyme mutations correlate with increased susceptibility to some cancers Homo sapiens
3.1.11.1 metabolism exonuclease 1 is a multifunctional 5'->3' exonuclease and a DNA structure-specific DNA endonuclease Homo sapiens
3.1.11.1 physiological function the enzyme plays roles in telomere maintenance, DNA replication, DNA mismatch repair and DNA double-stranded break repair and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining Homo sapiens